14398-42-6Relevant articles and documents
CuH-Catalyzed Asymmetric Reductive Amidation of α,β-Unsaturated Carboxylic Acids
Link, Achim,Zhou, Yujing,Buchwald, Stephen L.
supporting information, p. 5666 - 5670 (2020/07/24)
The direct enantioselective copper hydride (CuH)-catalyzed synthesis of β-chiral amides from α,β-unsaturated carboxylic acids and secondary amines under mild reaction conditions is reported. The method utilizes readily accessible carboxylic acids and tolerates a variety of functional groups in the β-position including several heteroarenes. A subsequent iridium-catalyzed reduction to γ-chiral amines can be performed in the same flask without purification of the intermediate amides.
Synthesis and structure-activity relationships of 2- pyrazinylcarboxamidobenzoates and β-ionylideneacetamidobenzoates with retinoidal activity
Jones, Paul,Villeneuve, Gérald B.,Fei, Chengpei,DeMarte, Josie,Haggarty, Allison J.,Nwe, Khin Than,Martin, Deborah A.,Lebuis, Anne-Marie,Finkelstein, Joshua M.,Gour-Salin, Barbara J.,Chan, Tak Hang,Leyland-Jones, Brian R.
, p. 3062 - 3077 (2007/10/03)
The structure-activity relationships of two series of novel retinoids (2-pyrazinylcarboxamidobenzoates and β-ionylideneacetamidobenzoates) have been investigated by evaluating their ability to induce differentiation in both human promyelocytic leukemia (H
Ionylideneacetic Acids and Abscisic Acid Biosynthesis by Cercospora rosicola
Norman, Shirley M.,Poling, Stephen M.,Maier, V. P.,Nelson, Mary D.
, p. 2317 - 2324 (2007/10/02)
Several compounds having the basic α-ionylideneacetic acid stucture were tested in Cercospora rosicola resuspensions.At 100 μM, all the compounds inhibited abscisic acid (ABA) biosynthesis.Time studies with unlabelled and deuterated (2Z,4E)- and (2E,4E)-α