1440509-95-4

Basic information

• Product Name: C₂₈H₄₀N₈O₃
• CAS NO: 1440509-95-4
• Molecular Weight: 536.677
• Mol File: 1440509-95-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₈H₄₀N₈O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₄₀N₈O₃(1440509-95-4)
• EPA Substance Registry System: C₂₈H₄₀N₈O₃(1440509-95-4)

Safety Data

• Hazardous Substances Data: 1440509-95-4(Hazardous Substances Data)

Upstream product

• 902799-70-6 C₂₇H₃₆SiO₄ 
• 1440510-01-9 C₂₅H₃₂O₄Si 
• 303963-92-0 (3aR,6aR)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-2,2-dimethyl-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-one 
• 303963-93-1 (3aS,4S,6aR)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-2,2-dimethyl-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-ol 
• 1440510-02-0 C₃₀H₃₃ClN₄O₃Si 
• 79386-50-8 (3'R,4'S,5'R)-3'-(6-aminopurin-9-yl)-1'-hydroxymethyl-4',5'-O-isopropylidene-cyclopent-1'-en-4',5'-diol 
• 952418-12-1 (1R,4R,5S)-9-[3-(tert-butyldiphenylsilyloxymethyl)-4,5-isopropylidenedioxy-2-cyclopenten-1-yl]adenine 

Relevant articles and documents

Synthesis, activity and metabolic stability of non-ribose containing inhibitors of histone methyltransferase DOT1L

Histone methyltransferase DOT1L is a drug target for MLL leukemia. We report an efficient synthesis of a cyclopentane-containing compound that potently and selectively inhibits DOT1L (Ki = 1.1 nM) as well as H3K79 methylation (IC50 ～