144052-40-4

Basic information

• Product Name: m-Xylylenediphosphonic Acid
• Synonyms: m-Xylylenediphosphonic Acid;3-[(Phosphonomethyl)phenyl]methylphosphonic acid;m-Xylylenediphosphonic Acid
• CAS NO: 144052-40-4
• Molecular Formula: C₈H₁₂O₆P₂
• Molecular Weight: 266.124802
• EINECS: -0
• Mol File: 144052-40-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 216 °C
• Appearance: /
• CAS DataBase Reference: m-Xylylenediphosphonic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: m-Xylylenediphosphonic Acid(144052-40-4)
• EPA Substance Registry System: m-Xylylenediphosphonic Acid(144052-40-4)

Safety Data

• RIDADR: UN 3261 8/PG III
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 144052-40-4(Hazardous Substances Data)

Usage

General Description

m-Xylylenediphosphonic Acid is a chemical compound with the formula C8H10O6P2. It is a phosphonic acid-based compound that is used as a chelating agent in various industrial applications. m-Xylylenediphosphonic Acid is commonly used in water treatment, metal cleaning, and metal surface treatment processes. It can effectively bind to metal ions and prevent them from precipitating, thus improving the overall efficiency of the industrial processes. m-Xylylenediphosphonic Acid is also used as a corrosion inhibitor for cooling water systems and as a scale inhibitor in oilfield applications. Its ability to form stable complexes with metal ions makes it a valuable component in various industrial processes.

Upstream product

• 56875-38-8 tetraethyl [1,3-phenylenedi(methylene)]bis(phosphonate) 
• 122-52-1 triethyl phosphite 
• 626-15-3 1,3-bis-(bromomethyl)benzene 
• 626-18-6 1,3-dimethanol benzene 
• 144052-39-1 1,3-phenylenebis(methylene)bisphosphonic acid tetramethyl ester 

Downstream Products

• 1564243-83-9 [Cd(o-phen)(1,3-HO₃PC₈H₈PO₃H)] 
• 1564243-80-6 [Cd(bpy)(1,3-HO₃PC₈H₈PO₃H)] 
• 1564243-75-9 [Zn(o-phen)(1,3-HO₃PC₈H₈PO₃H)]*(H₂O) 
• 1564243-66-8 [Zn(bpy)(1,3-HO₃PC₈H₈PO₃H)]*(H₂O) 
• 1444154-34-0 [Cu(1,10-phenanthroline)(m-xylenediphosphonic acid(-2H))] 

Relevant articles and documents

Rapid one-pot synthesis of alkane-α ω, diylbisphosphonic acids from dihalogenoalkanes under microwave irradiation

A one-pot, two-step synthesis of alkylenebisphosphonic acids from dihalogenoalkanes was performed under microwave irradiation. The reaction is very rapid and convenient for the synthesis of small samples of alkylenebisphosphonic acids. Copyright Taylor & Francis Group, LLC.

The synthesis of novel bisphosphonates as inhibitors of phosphoglycerate kinase (3-PGK)

A series of conformationally-restrained analogues of 1,3-bisphospho-D-glyceric acid (1,3-BPG) 1 has been synthesised for use as inhibitors of 3-PGK (E.C. 2.7.2.3). These compounds have non-scissile phosphonate linkages and also incorporate α-halogen substituents to make them isopolar and isosteric mimics of the natural substrate. A monocyclic aryl core between the two phosphoryl centres provides both a rigid framework linking these moieties and loci for further substitution. The compounds were tested against human 3-PGK and found to be good competitive inhibitors. α-Fluorination of the phosphonic acids increased the affinity for the enzyme into the submicromolar range. Correlation of IC50 data with pKa. and pKa, values indicates that the acidity of the phosphoryl group exerts a strong influence on protein binding. The Royal Society of Chemistry 2000.

(o-Hydroxyphenyl)methylphosphonic acids: Synthesis and Potentiometric Determinations of their pKa Values

(o-Hydroxyphenyl)methylphosphonic acids are readily obtained from o-(bromomethyl)- or o-(hydroxymethyl)phenols and trialkyl phosphites.Subsequent hydrolysis leads to the corresponding phosphonic acids.For a series of such compounds, the pKa val