144084-01-5 Usage
Description
1-O-Acetyl-2,3,5-tri-O-(4-chlorobenzoyl)-beta-D-ribofuranose is a complex organic compound characterized by its white solid appearance. It is a derivative of beta-D-ribofuranose, a sugar alcohol, with specific modifications that include the presence of an acetyl group at the first position and three 4-chlorobenzoyl groups attached to the second, third, and fifth positions.
Uses
1. Used in Pharmaceutical Industry:
1-O-Acetyl-2,3,5-tri-O-(4-chlorobenzoyl)-beta-D-ribofuranose is used as an intermediate in the synthesis of Clitocine, a compound with potential pharmaceutical applications. Its unique chemical structure allows it to serve as a key component in the development of new drugs or drug candidates.
2. Used in Chemical Research:
As a white solid with distinct chemical properties, 1-O-Acetyl-2,3,5-tri-O-(4-chlorobenzoyl)-beta-D-ribofuranose can be utilized in various chemical research applications. It may be employed in the study of organic reactions, synthesis methods, and the development of novel chemical compounds with potential applications in different industries.
3. Used in Material Science:
The compound's unique structure and properties may also find applications in material science, where it could be used to develop new materials with specific characteristics, such as improved stability or reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 144084-01-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,0,8 and 4 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 144084-01:
(8*1)+(7*4)+(6*4)+(5*0)+(4*8)+(3*4)+(2*0)+(1*1)=105
105 % 10 = 5
So 144084-01-5 is a valid CAS Registry Number.
InChI:InChI=1/C28H21Cl3O9/c1-15(32)37-28-24(40-27(35)18-6-12-21(31)13-7-18)23(39-26(34)17-4-10-20(30)11-5-17)22(38-28)14-36-25(33)16-2-8-19(29)9-3-16/h2-13,22-24,28H,14H2,1H3/t22-,23-,24-,28-/m1/s1
144084-01-5Relevant articles and documents
Synthesis and enzymatic activity of some new purine ring system analogues of adenosine 3',5'-cyclic monophosphate
Sagi,Szucs,Vereb,Otvos
, p. 4549 - 4556 (2007/10/02)
A series of novel adenosine 3',5'-cyclic monophosphate (cAMP) analogues, as well as their 6-deamino and 6-nitro derivatives, were synthesized where the purine ring was replaced by indazole, benzotriazole, and benzimidazole. The 3',5'-cyclic monophosphates of indazole and benzotriazole ribofuranosides, where the sugar-phosphate moiety is attached to the N-2 nitrogen atoms of the heterocycles, were also prepared. The biological efficiency of the analogues was tested by their ability to activate purified cAMP-dependent protein kinase I (PK-I) from rabbit skeletal muscle and cAMP- dependent protein kinase II (PK-II) from bovine heart. Each cyclic nucleotide is capable of activating both PK isozymes in half-maximum concentrations (K(a)) ranging from 2.0 · 10-8 to 4.8 · 10-6 M. The cyclic phosphate of N-1-β-D-ribofuranosylindazole (13) proved to be a very poor activator for both PK-I and PK-II, but when indazole binds by N-2 to ribose or when the hydrogen atom at C-4 is substituted by a nitro or amino group, activities of the analogues increase considerably. The activating potencies of benzotriazole derivatives are similar to that of cAMP, irrespective of the C- 4 substituents. The K(a)' values of cyclic nucleotides containing benzimidazole were found to be higher for PK-II than for PK-I; e.g. the activity of 4-nitro-1-β-D-ribofuranosylbenzimidazole 3',5'-cyclic monophosphate (32) is nearly 20 times as high for PK-II than for PK-I.