144089-97-4

Basic information

• Product Name: 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-N-(2-methyl-1-oxopropyl)guanosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
• Synonyms: 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-N-(2-methyl-1-oxopropyl)guanosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite];DMT-2FLUORO-DG(IB) AMIDITE;DMT-2'-F-dG(iBu)-CE Phosphoramidite;2'-F-dG(iBu)-CE Phosphoramidite
• CAS NO: 144089-97-4
• Molecular Formula: C44H53FN7O8P
• Molecular Weight: 857.9058842
• Mol File: 144089-97-4.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C
• PKA: 9.16±0.20(Predicted)
• CAS DataBase Reference: 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-N-(2-methyl-1-oxopropyl)guanosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite](CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-N-(2-methyl-1-oxopropyl)guanosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite](144089-97-4)
• EPA Substance Registry System: 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-N-(2-methyl-1-oxopropyl)guanosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite](144089-97-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 144089-97-4(Hazardous Substances Data)

Usage

Description

5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-N-(2-methyl-1-oxopropyl)guanosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] is a complex organic compound with a unique molecular structure. It is a nucleoside derivative that plays a significant role in the field of molecular biology and pharmaceuticals due to its potential applications in the development of modified nucleotides and RNA interference (RNAi) technologies.

Uses

Used in Molecular Biology Applications:
5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-N-(2-methyl-1-oxopropyl)guanosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] is used as a building block for the preparation of cyclic dinucleotide compounds. These compounds are essential for various cellular processes, including signal transduction and gene regulation.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-N-(2-methyl-1-oxopropyl)guanosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] is used as a key intermediate in the synthesis of 4''-C-methoxy-2''-deoxy-2''-fluoro modified ribonucleotides. These modified ribonucleotides are crucial for improving the metabolic stability of RNA molecules and enhancing the efficiency of RNAi-mediated gene silencing, a promising therapeutic approach for various diseases.
Used in RNA Interference (RNAi) Technology:
5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-N-(2-methyl-1-oxopropyl)guanosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] is employed as a component in the development of RNAi technologies. RNAi is a powerful tool for gene silencing, which has potential applications in the treatment of genetic disorders, viral infections, and cancer. The compound contributes to the design and synthesis of small interfering RNA (siRNA) molecules with enhanced stability and efficacy.