144265-47-4

Basic information

• Product Name: 2H-Pyran, tetrahydro-2-(3-methylphenoxy)-
• CAS NO: 144265-47-4
• Molecular Formula: C12H16O2
• Molecular Weight: 192.258
• Mol File: 144265-47-4.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 2H-Pyran, tetrahydro-2-(3-methylphenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyran, tetrahydro-2-(3-methylphenoxy)-(144265-47-4)
• EPA Substance Registry System: 2H-Pyran, tetrahydro-2-(3-methylphenoxy)-(144265-47-4)

Safety Data

• Hazardous Substances Data: 144265-47-4(Hazardous Substances Data)

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 108-39-4 3-methyl-phenol 

Downstream Products

• 189574-85-4 (E)-ethyl 3-(2-hydroxy-4-methylphenyl)acrylate 
• 198197-91-0 Trimethyl-[4-methyl-2-(tetrahydro-pyran-2-yloxy)-phenyl]-silane 
• 259209-25-1 (2-hydroxy-4-methylphenyl)boronic acid 
• 108-39-4 3-methyl-phenol 
• 914094-53-4 2-(3-(bromomethyl)phenoxy)tetrahydro-2H-pyran 

Relevant articles and documents

Supported N-propylsulfamic acid onto Fe3O4 magnetic nanoparticles as a reusable and efficient nanocatalyst for the protection/deprotection of hydroxyl groups and protection of aldehydes

N-propylsulfamic acid supported onto Fe3O4 magnetic nanoparticles (MNPs-PSA) as an efficient and magnetically reusable nanocatalyst has been reported for the tetrahydropyranylation/depyranylation of a wide variety of alcohols and phenols by changing the solvent medium. Also, the protection of aldehydes as acylals using Ac2O in the presence of catalytic amount MNPs-PSA in good to high yields at room temperature under solvent-free conditions is described. After completing the reaction, the catalyst was easily separated from the reaction mixture with the assistance of an external magnetic field and reused for several consecutive runs without significant loss of their catalytic efficiency.

Pyrrolopyrazole derivative, preparation method and medical application thereof

The invention relates to pyrrolopyrazole derivative, a preparation method and application thereof in medicines. Specifically, the invention relates to a new pyrrolopyrazole derivative as shown in a general formula (I), a preparation method and application of the pyrrolopyrazole derivative or a pharmaceutical composition containing the pyrrolopyrazole derivative as a therapeutic agent, particularlyas a gastric acid secretion inhibitor and potassium-competitive acid blockers (P-CABs) in biological medicines. Specifically, the substituents (R1, R2, R3 and R4) in the general formula (I) are the same as the definitions in the specification.

Selective tetrahydropyranylation of alcohols and phenols using titanium(IV) salophen trifluoromethanesulfonate as an efficient catalyst

Titanium(IV) salophen trifluoromethanesulfonate, [TiIV(salophen)(OSO2CF3)2], as a catalyst enables selective tetrahydropyranylation of alcohols and phenols with 3,4-dihydro-2H-pyran. Using this catalytic system, primary, secondary and tertiary alcohols, as well as phenols, were converted to their corresponding tetrahydropyranyl ethers in high yields and short reaction times at room temperature. Investigation of the chemoselectivity of this method showed discrimination between the activity of primary alcohols in the presence of secondary and tertiary alcohols and phenols. This heterogenized catalyst could be reused several times without loss of its catalytic activity. Copyright