1442656-59-8

Basic information

• Product Name: C₁₂H₁₅N₃O₂
• CAS NO: 1442656-59-8
• Molecular Weight: 233.27
• Mol File: 1442656-59-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₅N₃O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₅N₃O₂(1442656-59-8)
• EPA Substance Registry System: C₁₂H₁₅N₃O₂(1442656-59-8)

Safety Data

• Hazardous Substances Data: 1442656-59-8(Hazardous Substances Data)

Upstream product

• 55792-53-5 acetic acid-(3-butoxy-anilide) 
• 6294-89-9 hydrazinecarboxylic acid methyl ester 
• 23079-68-7 3-n-butoxyaniline 
• 122-51-0 orthoformic acid triethyl ester 

Relevant articles and documents

Design, synthesis, and anticonvulsant activity evaluation of 4-(3-Alkoxy-phenyl)-2,4-dihydro-[1,2,4]triazol-3-ones

A series of 4-(3-alkoxy-phenyl)-2,4-dihydro-[1,2,4]triazol-3-ones were synthesized using the appropriate synthetic route and evaluated experimentally in the maximal electroshock test; their neurotoxicities were evaluated by the rotarod neurotoxicity test. The structures of these compounds were confirmed by IR, MS, 1H-NMR, and elementary analysis. All target compounds exhibited anticonvulsant activity to varying degrees in the maximal electroshock test. 4-(3-Benzyloxy-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one (4i) was the most promising compound with an ED50 value of 30.5 mg/kg and a protective index (PI) of 18.63, showing a higher safety than the standard carbamazepine (PI = 6.45). In addition, the potency of compound 4i against seizures induced by pentylenetetrazole and 3-mercaptopropionic acid suggested its broad-spectrum activity, and the mechanisms of action including inhibition of voltage-gated ion channels and modulation of GABAergic activity might be involved in its anticonvulsant activity. Copyright