1443542-89-9

Basic information

• Product Name: 3-bromo-5-(4-methylphenyl)-2(1H)-pyridinone
• Synonyms: 3-bromo-5-(4-methylphenyl)-2(1H)-pyridinone
• CAS NO: 1443542-89-9
• Molecular Weight: 264.121
• Mol File: 1443542-89-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-bromo-5-(4-methylphenyl)-2(1H)-pyridinone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-5-(4-methylphenyl)-2(1H)-pyridinone(1443542-89-9)
• EPA Substance Registry System: 3-bromo-5-(4-methylphenyl)-2(1H)-pyridinone(1443542-89-9)

Safety Data

• Hazardous Substances Data: 1443542-89-9(Hazardous Substances Data)

Upstream product

• 5720-05-8 4-methylphenylboronic acid 
• 157020-26-3 pyridinium N-<2'-(5'-bromopyridyl)>aminide 
• 910791-86-5 N-[(3'-bromo-5'-(4''-methylphenyl))pyridin-2-yl]pyridinium aminide 
• 808750-47-2 N-[5-(4-methylphenyl)pyridin-2-yl]pyridin-1-ium-1-aminide 
• 1381942-60-4 3-bromo-5-(4-methylphenyl)-2-pyridinamine 

Relevant articles and documents

A facile synthesis of 3,5-halo and aryl 1H-pyridin-2-ones from pyridinium N-(pyridin-2-yl)aminide

The synthesis of halogenated and arylated 1H-pyridin-2-ones starting from pyridinium N-(pyridin-2-yl)aminides is described. The synthetic pathway involves the reaction of pyridinium N-(5-bromopyridin-2-yl)aminide, N-(3-bromo-5- chloropyridin-2-yl)aminide or N-(3,5-dibromopyridin-2-yl)aminide with different boronic acids to afford monosubstituted and disubstituted aminides in good yields. An additional bromination in the 3-position of N-(5-arylpyridin-2-yl) aminides was performed. Finally, reduction of the N-N bond followed by the reaction of the corresponding 2-aminopyridines with sodium nitrite/sulfuric acid in water yields 3,5-disubstituted 1H-pyridin-2-ones in good yields.