1443753-06-7

Basic information

• Product Name: (R)-2-(benzyloxy)-1-(3-methylpyrrolidin-1-yl)ethanone
• Synonyms: (R)-2-(benzyloxy)-1-(3-methylpyrrolidin-1-yl)ethanone
• CAS NO: 1443753-06-7
• Molecular Weight: 233.31
• Mol File: 1443753-06-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-2-(benzyloxy)-1-(3-methylpyrrolidin-1-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(benzyloxy)-1-(3-methylpyrrolidin-1-yl)ethanone(1443753-06-7)
• EPA Substance Registry System: (R)-2-(benzyloxy)-1-(3-methylpyrrolidin-1-yl)ethanone(1443753-06-7)

Safety Data

• Hazardous Substances Data: 1443753-06-7(Hazardous Substances Data)

Upstream product

• 19810-31-2 Benzyloxyacetyl chloride 
• 235093-98-8 (R)-3-methylpyrrolidine hydrogen chloride 

Downstream Products

• 1443752-89-3 C₃₃H₃₅NO₈ 
• 1443752-75-7 3-(4-hydroxyphenyl)-2-(4-(2-((R)-3-methylpyrrolidin-1-yl)ethoxy)phenyl)-4-(trifluoromethyl)-2H-chromen-7-ol 
• 1443773-55-4 2-(4-(2-((R)-3-methylpyrrolidin-1-yl)ethoxy)phenyl)-7-((tetrahydro-2H-pyran-2-yl)oxy)-3-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)chroman-4-one 
• 1443773-82-7 C₃₉H₄₉NO₇ 
• 474527-76-9 (R)-2-(3-methylpyrrolidin-1-yl)ethanol 
• 1443773-75-8 (3R)-3-methyl-1-(2-(4-(4-methyl-7-((tetrahydro-2H-pyran-2-yl)oxy)-3-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2H-chromen-2-yl)phenoxy)ethyl)pyrrolidine 
• 1443752-76-8 (2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-chromen-7-ol 
• 1443752-77-9 (2R)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-chromen-7-ol 
• 1443753-07-8 (R)-1-(2-(benzyloxy)ethyl)-3-methylpyrrolidine 
• 1443752-79-1 (2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-chromen-7-ol hydrochloride 
• 1443752-90-6 C₂₉H₃₁NO₅ 
• 1443752-93-9 C₃₅H₃₉NO₈ 
• 1443752-92-8 C₃₉H₄₇NO₆ 
• 1443752-91-7 C₂₉H₃₃NO₁₀P₂ 

Relevant articles and documents

COMBINATIONS OF BENZOPYRAN COMPOUNDS, COMPOSITIONS AND USES THEREOF

This invention relates to a method of treating a disorder modulated, mediated or affected by the estrogen receptor in a subject comprising administering to the subject a specific benzopyran (in the form of a mixture of S-C2 and R-C2 diastereomers or its pure S-diastereomer) in combination with an agent selected from the group consisting of an mTOR inhibitor, a CDK 4/6 inhibitor, a PI3 Kinase inhibitor, a taxane, an antimetabolite, and an antitumor antibiotic.

NOVEL BENZOPYRAN COMPOUNDS, COMPOSITIONS AND USES THEREOF

Benzopyran compounds with strong anti-estrogenic activity and essentially no estrogenic activity are provided, which are OP- 1038, which is 3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-l-yl]ethoxy}phenyl)-2H-chromen-7-ol, and OP-1074, which is (2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin- 1 -yl]ethoxy}phenyl)-2H-chromen-7-ol. OP-1074 is a pure anti-estrogen when tested in the agonist mode and a complete anti-estrogen when tested in the antagonist mode. These compounds are useful for the treatment or prevention of a variety of conditions that are modulated through the estrogen receptor in mammals including humans.