1443793-79-0

Basic information

• Product Name: 1,1-bis[4-(N,N′-di(tert-butoxycarbonyl)guanidinephenyl)]cyclohexane
• Synonyms: 1,1-bis[4-(N,N′-di(tert-butoxycarbonyl)guanidinephenyl)]cyclohexane
• CAS NO: 1443793-79-0
• Molecular Weight: 750.936
• Mol File: 1443793-79-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,1-bis[4-(N,N′-di(tert-butoxycarbonyl)guanidinephenyl)]cyclohexane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-bis[4-(N,N′-di(tert-butoxycarbonyl)guanidinephenyl)]cyclohexane(1443793-79-0)
• EPA Substance Registry System: 1,1-bis[4-(N,N′-di(tert-butoxycarbonyl)guanidinephenyl)]cyclohexane(1443793-79-0)

Safety Data

• Hazardous Substances Data: 1443793-79-0(Hazardous Substances Data)

Upstream product

• 108-94-1 cyclohexanone 
• 62-53-3 aniline 
• 3282-99-3 1,1-bis-(4-aminophenyl)cyclohexane 
• 145013-05-4 tert-butyl N-({[(tert-butoxy)carbonyl]amino}methanethioyl)carbamate 

Relevant articles and documents

Guanidine-guanidinium cooperation in bifunctional artificial phosphodiesterases based on diphenylmethane spacers; Gem -dialkyl effect on catalytic efficiency

Diphenylmethane derivatives 1-3, decorated with two guanidine units, are effective catalysts of HPNP transesterification. Substitution of the methylene group of the parent diphenylmethane spacer with cyclohexylidene and adamantylidene moieties enhances catalytic efficency, with gem-dialkyl effect accelerations of 4.5 and 9.1, respectively. Activation parameters and DFT calculations of the rotational barriers around the C-Ar bonds indicate that a major contribution to the driving force for enhanced catalysis is entropic in nature.