144400-95-3

Basic information

• Product Name: 4-methyl-5-[(2E)-3-phenylprop-2-enoyl]-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one
• CAS NO: 144400-95-3
• Molecular Formula: C₁₉H₁₈N₂O₂
• Molecular Weight: 306.3584
• Mol File: 144400-95-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 496.6°C at 760 mmHg
• Flash Point: 254.1°C
• Density: 1.188g/cm³
• Vapor Pressure: 5.34E-10mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: 4-methyl-5-[(2E)-3-phenylprop-2-enoyl]-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-5-[(2E)-3-phenylprop-2-enoyl]-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one(144400-95-3)
• EPA Substance Registry System: 4-methyl-5-[(2E)-3-phenylprop-2-enoyl]-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one(144400-95-3)

Safety Data

• Hazardous Substances Data: 144400-95-3(Hazardous Substances Data)

Upstream product

• 3967-01-9 4-methyl-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one 
• 102-92-1 Cinnamoyl chloride 

Relevant articles and documents

Synthesis and immunotropic properties of 5-substituted 1,5-benzodiazepin-2-ones derivatives in cultures of human peripheral blood cells, Part III

The reaction of 4-methyl-(A) and 3-methyl-1H-2,3,4,5-tetrahydro-1,5-benzodiazepin-2-one (B) with selected α,β-unsaturated acid chlorides: crotonoyl, cinnamoyl, and 4-nitrocinnamoyl is described. We have also characterized immunotropic activities of these compounds in the proliferative response of human lymphocytes to phytohemagglutinin A (PHA) or to allogeneic cells in one-way mixed lymphocyte reaction (MLR), as well as their action on tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) production in peripheral blood mononuclear cells (PBMC) and mixed lymphocyte cultures (MLC). Some of the compounds exhibited regulatory activities in the proliferative response of cells to PHA depending on the reactivity of cells to PHA. The MLR induced proliferation of lymphocytes was moderately inhibited by two selected compounds. The compounds showed also inhibitory properties with regard to lipopolysaccharide (LPS)- and MLR-induced TNF-α production. Structure-activity relationship was discussed.