144409-60-9Relevant articles and documents
α-C-H Bond Functionalization of Unprotected Alicyclic Amines: Lewis-Acid-Promoted Addition of Enolates to Transient Imines
Kim, Jae Hyun,Paul, Anirudra,Ghiviriga, Ion,Seidel, Daniel
supporting information, p. 797 - 801 (2021/02/06)
Enolizable cyclic imines, obtained in situ from their corresponding lithium amides by oxidation with simple ketone oxidants, are readily alkylated with a range of enolates to provide mono- and polycyclic β-aminoketones in a single operation, including the natural product (±)-myrtine. Nitrile anions also serve as competent nucleophiles in these transformations, which are promoted by BF3 etherate. β-Aminoesters derived from ester enolates can be converted to the corresponding β-lactams.
A method for synthesizing compound of [...]
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Paragraph 0033; 0034, (2017/03/28)
The invention relates to quinolizidine compounds, particularly a synthesis method of a quinolizidine ketone compound. The method comprises the following steps: carrying out aza Diels-Alder reaction on a compound 1 chloroacylbutyl amine in a halohydrocarbon solvent or alcohol solvent at 0-30 DEG C under the actions of fluoroform sulfonic anhydride, silane, organic base and diolefin, carrying out hydrochloric acid treatment, extracting, drying, concentrating, and purifying to obtain a compound 2 chloro-2,3-dihydro-4-pyridone; carrying out iodo reaction on the compound 2 chloro-2,3-dihydro-4-pyridone in a ketone solvent at 30-90 DEG C under the action of an iodate, extracting, drying, concentrating and purifying to obtain a compound 3-iodo-2,3-dihydro-4-pyridone; and reacting the compound 3 in a halohydrocarbon solvent at 60-100 DEG C under the actions of an initiator and a reducer, concentrating, and purifying to obtain the compound 4 quinolizidine ketone compound.
Synthetic applications of sulfur-substituted indolizidines and quinolizidines
Chou, Shang-Shing P.,Chung, Yi-Ching,Chen, Po-An,Chiang, Shan-Lun,Wu, Chien-Jung
experimental part, p. 692 - 695 (2011/03/20)
Starting from the sulfur-substituted indolizidines and quinolizidines, a few useful synthetic transformations have been developed and the synthesis of some natural products including indolizidine 209D, epimyrtine, lasubine II, 8a-epi-dendroprimine, and 5-