1445-45-0Relevant articles and documents
Process for producing high-quality trimethyl orthoacetate
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Paragraph 0014; 0015; 0016; 0017; 0018; 0019, (2018/04/21)
The invention discloses a process for producing high-quality trimethyl orthoacetate. The process comprises the steps of: in the presence of a pseudocumene solvent, performing a salt-forming reaction on acetonitrile, methanol and hydrogen chloride to prepare ethylenediamine methyl ether hydrochloride, then putting the obtained ethylenediamine methyl ether hydrochloride in a methanol solution, adding an ammonium methanol solution dropwise so as to adjust the pH value, performing an alcoholysis reaction to obtain a crude product of trimethyl orthoacetate, performing filtration so as to remove solid ammonium chloride for recycling, performing adsorption on the obtained filtrate by using strongly alkaline macroporous ion exchange resin so as to remove chloride ions, and finally performing continuous rectification to obtain the trimethyl orthoacetate product which has a content of more than 99.5% and a yield of more than 85%. The process is simple, the product is stable and reliable, the adopted pseudocumene solvent has low toxicity and is safe to use.
A hydrogen chloride producing toluene diisocyanate methyl-acetate production method
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Paragraph 0047-0060, (2017/02/24)
The invention discloses a method for producing trimethyl orthoacetate by utilizing hydrogen chloride (HCl) generated during production of toluene diisocynate (TDI). The method comprises the following steps: carrying out pressure boosting on a dried normal-pressure and low-temperature HCl waste gas taken as a byproduct during production of TDI and then feeding methyl alcohol into HCl so as to prepare an alcohol acid; carrying out a salt forming reaction on the alcohol acid and acetonitrile in an inert solvent so as to prepare an ethyleneimine methyl ether hydrochloride; feeding methyl alcohol twice, carrying out an alcoholysis reaction and distilling so as to prepare trimethyl orthoacetate. According to the method, dried normal-pressure and low-temperature HCl generated during the production of TDI is taken a raw material, namely, the recycling of a waste material is realized, so that the cost is lowered; the safety and the environmental friendliness are realized. The alcohol acid is prepared, so that the problems that the metering of HCl is inaccurate and the temperature is difficult to control because a large quantity of heat is released during the salt forming reaction are solved; the solvent with a high boiling point is used, so that the safe and environment-friendly problem that the solvent with a low boiling point is toxic and flammable is solved; the continuous rectification is carried out, so that the problem of long production cycle is solved. The yield of prepared trimethyl orthoacetate can reach 76% to 80%.
Orthoester exchange: A tripodal tool for dynamic covalent and systems chemistry
Brachvogel, Ren-Chris,Von Delius, Max
, p. 1399 - 1403 (2015/02/05)
Reversible covalent reactions have become an important tool in supramolecular chemistry and materials science. Here we introduce the acid-catalyzed exchange of O,O,O-orthoesters to the toolbox of dynamic covalent chemistry. We demonstrate that orthoesters readily exchange with a wide range of alcohols under mild conditions and we disclose the first report of an orthoester metathesis reaction. We also show that dynamic orthoester systems give rise to pronounced metal template effects, which can best be understood by agonistic relationships in a three-dimensional network analysis. Due to the tripodal architecture of orthoesters, the exchange process described herein could find unique applications in dynamic polymers, porous materials and host-guest architectures.