1445778-71-1

Basic information

• Product Name: S-(3-amino-3-oxo-2-phenylpropyl)ethanethioate
• CAS NO: 1445778-71-1
• Molecular Weight: 223.296
• Mol File: 1445778-71-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: S-(3-amino-3-oxo-2-phenylpropyl)ethanethioate(CAS DataBase Reference)
• NIST Chemistry Reference: S-(3-amino-3-oxo-2-phenylpropyl)ethanethioate(1445778-71-1)
• EPA Substance Registry System: S-(3-amino-3-oxo-2-phenylpropyl)ethanethioate(1445778-71-1)

Safety Data

• Hazardous Substances Data: 1445778-71-1(Hazardous Substances Data)

Upstream product

• 14485-09-7 2-phenylacrylamide 
• 507-09-5 tiolacetic acid 
• 51491-68-0 2-phenylacrylyl chloride 
• 492-38-6 2-phenylacrylic acid 

Relevant articles and documents

Convenient synthesis of various substituted homotaurines from alk-2-enamides

Various substituted homotaurines (=3-aminopropane-1-sulfonic acids) 6 were readily synthesized in satisfactory to good yields via the Michael addition of thioacetic acid to alk-2-enamides 3 (→4), followed by LiAlH4 reduction (→5) and performic acid oxidation (Scheme 1). The configuration of 'anti'-disubstituted homotaurine 'anti'-6h was deduced from the 3-(acetylthio)alkanamide (=S-(3-amino-1,2-dimethyl-3-oxopropyl) ethanethioate)'anti'-4h formed in the Michael addition, which was identified via the Karplus equation analysis, and confirmed by X-ray diffraction analysis. The current route is an efficient method to synthesize diverse substituted homotaurines, including 1-, 2-, and N-monosubstituted, as well as 1,2-, 1,N-, 2,N-, and N,N-disubstituted homotaurines (Table). Copyright