14458-05-0Relevant articles and documents
Tuning the electrocatalytic hydrogen evolution reaction promoted by [Mo2O2S2]-based molybdenum cycles in aqueous medium
Hijazi, Akram,Kemmegne-Mbouguen, Justin Claude,Floquet, Sébastien,Marrot, Jér?me,Fize, Jennifer,Artero, Vincent,David, Olivier,Magnier, Emmanuel,Pégot, Bruce,Cadot, Emmanuel
, p. 4848 - 4858 (2013)
We report the syntheses and characterizations, in the solid state and in solution, of three new cyclic polyoxothiomolybdates self-assembled around 2,5-dimethylterephthalate (DMT) and 2,5-bis(trifluoromethyl)terephthalate (DFMT) ligands, namely [Mo12DMT]2-, [Mo12DFMT] 2- and [Mo16DFMT]2-. A series of these two Mo12-compounds completed by the two Mo12-compounds obtained with 2,3,5,6-tetramethylterephthalate and trimesate ligands offer the opportunity to compare their electro-catalytic properties for reduction of protons into hydrogen. The ability of these compounds to promote the reduction of protons into hydrogen in aqueous medium is evidenced and the influence of the embedded ligand is highlighted, thus allowing proposal of a mechanism for the hydrogen evolution reaction catalyzed by these clusters.
SALE-Ing a MOF-Based “Ship of Theseus.” Sequential Building-Block Replacement for Complete Reformulation of a Pillared-Paddlewheel Metal-Organic Framework
Xu, Yan,Vermeulen, Nicolaas A.,Liu, Yangyang,Hupp, Joseph T.,Farha, Omar K.
, p. 4345 - 4348 (2016)
A complete structure and composition evolution of a pillared-paddlewheel metal-organic framework was achieved using a combination of solvent-assisted linker exchange (SALE) and node transmetalation. In this example, each building unit – the di-topic carboxylate strut, the di-topic nitrogen-based pillar, and the di-zinc node – of the original metal-organic framework is replaced in sequential fashion to produce a nickel-based daughter metal-organic framework with entirely different components.
Pore environment engineering in metal-organic frameworks for efficient ethane/ethylene separation
Wang, Xun,Niu, Zheng,Al-Enizi, Abdullah M.,Nafady, Ayman,Wu, Yufang,Aguila, Briana,Verma, Gaurav,Wojtas, Lukasz,Chen, Yu-Sheng,Li, Zhong,Ma, Shengqian
, p. 13585 - 13590 (2019)
Selective adsorption of trace amounts of C2H6 from bulk C2H4 is a significantly important and extremely challenging task in industry, which requires an adsorbent with specific pore properties. Herein, we describe a strategy for adjusting the pore environment of metal-organic frameworks (MOFs) by introducing different amounts of methyl groups in the channel to enhance the guest-host interaction between C2H6 and the framework. To prove this concept, 2,3,5,6-tetramethylterephthalic acid (TMBDC) was deliberately added to a microporous MOF, Ni(BDC)(DABCO)0.5, affording a series of mixed-ligand materials, Ni(BDC)1-x(TMBDC)x(DABCO)0.5 (x = 0, 0.2, 0.45, 0.71, 1), having different pore environments. Significantly, these mixed-ligand materials demonstrated improved performance in terms of the adsorption capacity of C2H6 and C2H4 with an unprecedented C2H6 uptake of 2.21 mmol g-1 for Ni(TMBDC)(DABCO)0.5 at 0.0625 bar and 298 K. With the best theoretical C2H6/C2H4 selectivity predicted by IAST, Ni(TMBDC)(DABCO)0.5 exhibited effective separation of C2H6/C2H4 (1/15, v/v) and great recyclability in five consecutive adsorption/desorption cycles throughout the breakthrough experiment.
Aryl(trimethylsilyl)selenides as reagents for the synthesis of mono- and diselenoesters
Taher, Deeb,Corrigan, John F.
experimental part, p. 5943 - 5952 (2012/01/04)
Silylated organoselenium reagents react undermild conditions with acid chlorides to provide a high yield route to aromatic selenoesters. The synthesis, structures, and spectroscopic properties of the selenoesters C 6H5SeC(O)R(R=CH2CH3, 1; p-CH 3C6H4, 2; p-C6Me4Br, 3; p-C6Me4C-(O)SeC 6H5, 4) and RC(O)SeFcSeC(O)R (Fc = Fe(C5H4)2;R=CH 2CH3, 5; p-CH3C6H4, 6; p-BrC6Me4, 7) and RC(O)Se(C6H4)nSeC(O)R (n = 1, R=CH2CH3, 8a; n = 2, R =CH2CH3, 8b; n = 1, R= p-CH3C 6H4, 9a; n = 2, R=p-CH3C6H 4, 9b; n=1,R=p-C6Me4Br, 10a; n=2, R = p-C6Me4Br, 10b) andC 6H5SeC(O)CH2CH2C(O)SeC 6H5 11 are discussed. Although 11 can be prepared in high yield from the reaction of C6H5SeSiMe3 and ClC(O)CH 2CH2C(O)Cl in tetrahydrofuran solvent, similar reactions in the absence of solvent led to the competitive formation of both 11 and (C6H5Se)3CCH2CH2C(O)OSiMe3 12. The new selenoesters have been characterized by multinuclear NMR (1H, 13C, 77Se), IR, and UV-vis spectroscopies, electrospray mass spectrometry, and, for complexes 2, 4, 7, 10b, and 12, single-crystal X-ray diffraction. 2011 American Chemical Society.
ALKYL CARBOXYLATE SALTS AS SOLVENTS FOR HENKEL-RELATED PROCESSES
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Page/Page column 6-7, (2008/06/13)
Disclosed is the use of one or more molten salts or a mixture thereof for use as a reaction medium in a process for the preparation of an aromatic diacid which comprises heating an alkali metal salt of an aromatic monocarboxylic acid or asymmetrical aromatic dicarboxylic acid under pressure with carbon dioxide gas in the presence of a catalyst at suitable reaction conditions. The molten salt reaction medium provides advantages in a disproportionation reaction to produce, for example, purified terephthalic acid. In another aspect of the invention, novel methylated diacids are produced.
In Vivo Inhibition of Cathepsin B by Peptidyl (Acyloxy)methyl Ketones
Wagner, Bonnie M.,Smith, Roger A.,Coles, Peter J.,Copp, Leslie J.,Ernest, Michael J.,Krantz, Allen
, p. 1833 - 1840 (2007/10/02)
Peptidyl (acyloxy)methyl ketones previously established as potent irreversible inhibitors of the cysteine proteinase cathepsin B in vitro, were investigated and optimized for their inhibitory activity in vivo.Incorporation of polar or charged functional groups in the inhibitor structure afforded effective cathepsin B inhibition, following dosing to rats.The most effective inhibitor, Z-Phe-Lys-CH2OCO-(2,4,6-Me3)Ph (8), was found to give ED50 values of 18 mg/kg po (orally) and 5.0 mg/kg ip (intraperitoneally) at 4-5 h postdose, and 2.4 mg/kg sc (subcutaneously) at 24h postdose, for liver cathepsin B inhibition (measured ex vivo).The subcutaneous route of administration of (acyloxy)methyl ketone 8 also provided potent cathepsin B inhibition in certain peripheral tissues (e.g., ED50 1.0 mg/kg for skeletal muscle, 0.1 mg/kg for heart).These investigations demonstrate that peptidyl (acyloxy)methyl ketones such as 8 have promise as tools for the characterization of in vivo biochemical processes and as therapeutic agents.
ARYLOXY AND ARYLACYLOXY METHYL KETONES AS THIOL PROTEASE INHIBITORS
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, (2008/06/13)
Thiol protease inhibitors are disclosed having the formula: STR1 or an optical isomer thereof, or a pharmaceutically acceptable salt thereof, wherein:n is 0 or 1;m is 0, 1 or 2;X is H or an N-protecting group; each Y is independently an optionally protected α-amino acid residue;R is an optionally protected α-amino acid side chain that is H or CH 3 or that is bonded to the α-carbon atom to which it is attached by a methylene, methine or phenyl radical; andR' is optionally substituted aryl.
