1446417-04-4Relevant articles and documents
Dynamic combinatorial chemistry with novel dithiol building blocks: Towards new structurally diverse and adaptive screening collections
Postma, Tobias M.,Galloway, Warren R.J.D.,Cougnon, Fabien B. L.,Panto?, G. Dan,Stokes, Jamie E.,Spring, David R.
, p. 765 - 769 (2013/05/09)
We describe the synthesis of a range of novel dithiol-functionalized building blocks and demonstrate how they can be used to generate new structurally diverse dynamic combinatorial libraries. A proof-of-principle experiment using the catecholamine dopamine revealed that molecular recognition changed the library composition under biocompatible conditions and identified new promising candidate receptors of this biologically important neurotransmitter. Georg Thieme Verlag Stuttgart - New York.