14467-32-4

Basic information

• Product Name: (S)-(+)-2-TERT-BUTYLAMINO-1-PHENYLETHAN&
• Synonyms: (S)-(+)-2-TERT-BUTYLAMINO-1-PHENYLETHAN&
• CAS NO: 14467-32-4
• Molecular Formula: C₁₂H₁₉NO
• Molecular Weight: 193.29
• Product Categories: Amino Alcohols;Chiral Building Blocks;Organic Building Blocks
• Mol File: 14467-32-4.mol
• Article Data: 29

Chemical Properties

• Melting Point: 105-108 °C(lit.)
• Boiling Point: 284°Cat760mmHg
• Flash Point: 80.7°C
• Appearance: /
• Density: 0.989g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.52
• CAS DataBase Reference: (S)-(+)-2-TERT-BUTYLAMINO-1-PHENYLETHAN&(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-2-TERT-BUTYLAMINO-1-PHENYLETHAN&(14467-32-4)
• EPA Substance Registry System: (S)-(+)-2-TERT-BUTYLAMINO-1-PHENYLETHAN&(14467-32-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 14467-32-4(Hazardous Substances Data)

Usage

General Description

(S)-(+)-2-tert-butylamino-1-phenylethan is a chemical compound with a molecular formula of C12H19N. It is a chiral compound with a molecular weight of 181.28 g/mol. (S)-(+)-2-TERT-BUTYLAMINO-1-PHENYLETHAN& is commonly used as a reactant in the synthesis of other organic compounds and pharmaceuticals. Its stereochemistry makes it useful for creating enantiomerically pure products, which is important in drug development and other applications where chirality is crucial. (S)-(+)-2-TERT-BUTYLAMINO-1-PHENYLETHAN& is also used as a building block in the synthesis of various biologically active molecules.

InChI:InChI=1/C12H19NO/c1-12(2,3)13-9-11(14)10-7-5-4-6-8-10/h4-8,11,13-14H,9H2,1-3H3/t11-/m1/s1

Upstream product

• 96-09-3 styrene oxide 
• 5577-67-3 trimethyl(tert-butylamino)silane 
• 100-42-5 styrene 
• 70111-05-6 (S)-2-chloro-1-phenylethanol 
• 75-64-9 tert-butylamine 
• 91850-96-3 2-(tert-butylimino)-1-phenylethanone 
• 119072-55-8 tert-butylisonitrile 
• 100-52-7 benzaldehyde 
• 7322-88-5 (S)-acetylmandelic acid 
• 17199-29-0 (S)-Mandelic acid 
• 469874-36-0 S(+)-N-tert-butyl-O-acetyl mandelamid 
• 79866-39-0 2-(tert-butylamino)-1-phenylethanone hydrochloride 
• 21504-13-2 2.5-Dihydroxy-3.6-diphenyl-1.4-dioxan 
• 6956-56-5 2,2-dimethoxy-1-phenylethanone 

Downstream Products

• 18366-84-2 3-tert-butyl-5r-phenyl-[1,2,3]oxathiazolidine 2t-oxide 
• 18366-84-2 3-tert-butyl-5r-phenyl-[1,2,3]oxathiazolidine 2c-oxide 
• 18366-49-9 1-tert-butyl-2-phenylaziridine 

Relevant articles and documents

Asymmetric Reduction of α-Ketoimines with Oxazaborolidine Catalysts: A Novel, Practical Approach to Chiral Arylethanolamines

Asymmetric borane reduction of α-ketoimines with oxazaborolidine catalysts has been studied.The ee's of the resulting arylethanolamines are uo to 93percent using 20 molpercent of the catalyst.

Efficient Synthesis of 2-Amino-1-Arylethanols Through a Lewis Base-Catalyzed SiCl4-Mediated Asymmetric Passerini-Type Reaction

We herein report, a practical and efficient strategy for the synthesis of enantiomerically enriched 2-amino-1-arylethanols, a structural motif commonly encountered in the family of β-adrenergic blockers or agonists, through a Lewis base-catalyzed SiClsub

Method for preparing beta-arylamino alcohol drugs such as tulobuterol, clorprenaline, dichloroisoprenaline and sotalol

The invention provides a method for preparing beta-arylamino alcohol drugs such as tulobuterol, clorprenaline, dichloroisoprenaline and sotalol. The beta-arylamino alcohol drugs have a chemical structure represented by a formula 4 shown in the description. The method comprises the following steps: (1) reacting arylethanone represented by a formula 1 shown in the description with a halogenating agent and sulfoxide to obtain arylglyoxal represented by a formula 2 shown in the description and or 1,1-dihydroxyarylethanone represented by a formula 3 shown in the description; and (2) performing a nucleophilic addition reaction on the arylglyoxal represented by the formula 2 and/or the 1,1-dihydroxyarylethanone represented by the formula 3 and an amine compound having a chemical formula of R1-NH2, and performing a reductive amination reaction in the presence of a reducing agent to obtain the beta-arylamino alcohol drugs.