1448041-24-4

Basic information

• Product Name: N-{2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1',1'-dioxido-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran]-5-yl}cyclopropanecarboxamide
• Synonyms: N-{2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1',1'-dioxido-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran]-5-yl}cyclopropanecarboxamide
• CAS NO: 1448041-24-4
• Molecular Weight: 518.63
• Mol File: 1448041-24-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-{2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1',1'-dioxido-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran]-5-yl}cyclopropanecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1',1'-dioxido-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran]-5-yl}cyclopropanecarboxamide(1448041-24-4)
• EPA Substance Registry System: N-{2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1',1'-dioxido-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran]-5-yl}cyclopropanecarboxamide(1448041-24-4)

Safety Data

• Hazardous Substances Data: 1448041-24-4(Hazardous Substances Data)

Upstream product

• 100277-27-8 (tetrahydro-2H-thiopyran-4-yl)methanol 
• 1448039-38-0 2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran] 1',1'-dioxide 
• 1448039-39-1 2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-5-nitro-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran] 1',1'-dioxide 
• 131992-30-8 4-(methoxymethylene)-3,4,5,6-tetrahydro-2H-thiopyran 
• 50675-19-9 4-thianylcarbaldehyde 
• 1448039-05-1 5-bromo-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran] 1',1'-dioxide 
• 1448038-91-2 5-bromo-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran] 
• 1448039-40-4 2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran]-5-amine 1',1'-dioxide 
• 1759-53-1 cyclopropanecarboxylic acid 
• 1448038-85-4 5-bromo-2-cyclopropyl-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran] 
• 1448038-82-1 5-bromo-2',3',5',6'-tetrahydrospiro[indole-3,4'-thiopyran] 
• 1072-72-6 Tetrahydrothiopyran-4-one 

Relevant articles and documents

SPIROINDOLINE DERIVATIVES AS GONADOTROPIN- RELEASING HORMONE RECEPTOR ANTAGONISTS

Spiroindoline derivatives, process for their preparation and pharmaceutical compositions thereof, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially sex-hormone-related diseases in both men and women, in particularly those selded from the group of endometriosis, uterine fibroids, polycystic ovarian disease, hirsutism, precocious puberty, gonadal steroid-dependent neoplasia such as cancers of the prostate, breast and ovary, gonadotrope pituitary adenomas, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hypertrophy, contraception and infertility (e.g., assisted reprodudive therapy such as in vitro fertilization). The present application relates in particular to spiroindoline derivatives as gonadotropin-releasing hormone (GnRH) receptor antagonists.