1448902-04-2

Basic information

• Product Name: 1-tert-butyl 3-methyl (3S,5R)-5-(benzyloxycarbonylamino)piperidine-1,3-dicarboxylate
• Synonyms: 1-tert-butyl 3-methyl (3S,5R)-5-(benzyloxycarbonylamino)piperidine-1,3-dicarboxylate
• CAS NO: 1448902-04-2
• Molecular Weight: 392.452
• Mol File: 1448902-04-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-tert-butyl 3-methyl (3S,5R)-5-(benzyloxycarbonylamino)piperidine-1,3-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-tert-butyl 3-methyl (3S,5R)-5-(benzyloxycarbonylamino)piperidine-1,3-dicarboxylate(1448902-04-2)
• EPA Substance Registry System: 1-tert-butyl 3-methyl (3S,5R)-5-(benzyloxycarbonylamino)piperidine-1,3-dicarboxylate(1448902-04-2)

Safety Data

• Hazardous Substances Data: 1448902-04-2(Hazardous Substances Data)

Upstream product

• 534572-20-8 (3S,5R)-1-(tert-butoxycarbonyl)-3-(methoxycarbonyl)piperidine-5-carboxylic acid 
• 499-81-0 3,5-Pyridinedicarboxylic acid 
• 4591-55-3 dimethyl pyridine-3,5-dicarboxylate 
• 920297-39-8 1-(tert-butoxycarbonyl)piperidine-3,5-dicarboxylic acid 
• 914260-44-9 2,4-dioxo-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylic acid tert-butyl ester 
• 100-51-6 benzyl alcohol 

Downstream Products

• 1448902-11-1 tert-butyl (3R,5S)-3-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-5-{[(1R)-1-(3-chlorophenyl)propyl]carbamoyl}piperidine-1-carboxylate 
• 1448902-12-2 tert-butyl (3R,5S)-3-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-5-{[(1R)-1-(4-chlorophenyl)propyl]carbamoyl}piperidine-1-carboxylate 
• 1263198-31-7 tert-butyl (3R,5S)-3-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-5-{[(1R)-1-(5-fluoro-2-pyridyl)-3-methylbutyl]carbamoyl}piperidine-1-carboxylate 
• 1448902-13-3 tert-butyl (3R,5S)-3-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-5-{[(1R)-1-(5-fluoro-3-pyridyl)-3-methylbutyl]carbamoyl}piperidine-1-carboxylate 
• 1448902-14-4 tert-butyl (3R,5S)-3-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-5-{[(1R)-1-isoxazol-5-yl-3-methylbutyl]carbamoyl}piperidine-1-carboxylate 
• 1448902-15-5 tert-butyl (3R,5S)-3-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-5-{[(1R)-3-methyl-1-oxazol-2-yl-butyl]carbamoyl}piperidine-1-carboxylate 
• 1263198-51-1 tert-butyl (3R,5S)-3-[2,2-dimethyl-4-(o-tolyl)-5-oxopiperazin-1-yl]-5-{[(1R)-1-(5-fluoro-2-pyridyl)-3-methylbutyl]carbamoyl}piperidine-1-carboxylate 
• 1263198-71-5 tert-butyl (3R,5S)-3-[4-(5-fluoro-2-methylphenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-5-{[(1R)-1-(5-fluoro-2-pyridyl)-3-methylbutyl]carbamoyl}piperidine-1-carboxylate 

Relevant articles and documents

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Synthesis and optimization of novel (3S,5R)-5-(2,2-dimethyl-5-oxo-4- phenylpiperazin-1-yl)piperidine-3-carboxamides as orally active renin inhibitors

We report synthesis and optimization of a series of (3S,5R)-5-(2,2- dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as renin inhibitors. Chemical modification of P1, P2 and P 3 portions led to a promising 3