1448992-15-1Relevant articles and documents
Palladium-catalyzed Hiyama cross-couplings of 2-chloro pyrimidines with organosilanes
Gong, Hai-Peng,Quan, Zheng-Jun,Wang, Xi-Cun
, (2022/01/19)
An efficient synthesis of C2-aryl pyrimidine derivatives via Pd-catalyzed Hiyama couplings has been developed. Various 2-chloro pyrimidines with electron-donating or electron-withdrawing groups as novel electrophile partners coupled well with trimethoxy(p
Structure elaboration of isoniazid: synthesis, in silico molecular docking and antimycobacterial activity of isoniazid–pyrimidine conjugates
Kaur, Hardeep,Singh, Lovepreet,Chibale, Kelly,Singh, Kamaljit
, p. 949 - 955 (2019/11/14)
Abstract: Designing small molecule-based new drug candidates through structure modulation of the existing drugs has drawn considerable attention in view of inevitable emergence of resistance. A new series of isoniazid–pyrimidine conjugates were synthesize
Ferrocene-pyrimidine conjugates: Synthesis, electrochemistry, physicochemical properties and antiplasmodial activities
Chopra, Rakesh,De Kock, Carmen,Smith, Peter,Chibale, Kelly,Singh, Kamaljit
, p. 1 - 9 (2015/08/18)
The promise of hybrid antimalarial agents and the precedence set by the antimalarial drug ferroquine prompted us to design ferrocene-pyrimidine conjugates. Herein, we report the synthesis, electrochemistry and anti-plasmodial evaluation of ferrocenyl-pyrimidine conjugates against chloroquine susceptible NF54 strain of the malaria parasite Plasmodium falciparum. Also their physicochemical properties have been studied.