1448992-18-4

Basic information

• Product Name: 2-chloro-4-(4-fluorophenyl)-6-methylpyrimidine-5-carboxylic acid ethyl ester
• Synonyms: 2-chloro-4-(4-fluorophenyl)-6-methylpyrimidine-5-carboxylic acid ethyl ester
• CAS NO: 1448992-18-4
• Molecular Weight: 294.713
• Mol File: 1448992-18-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-chloro-4-(4-fluorophenyl)-6-methylpyrimidine-5-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-4-(4-fluorophenyl)-6-methylpyrimidine-5-carboxylic acid ethyl ester(1448992-18-4)
• EPA Substance Registry System: 2-chloro-4-(4-fluorophenyl)-6-methylpyrimidine-5-carboxylic acid ethyl ester(1448992-18-4)

Safety Data

• Hazardous Substances Data: 1448992-18-4(Hazardous Substances Data)

Upstream product

• 1091909-58-8 4-(4-fluorophenyl)-2-hydroxy-6-methylpyrimidine-5-carboxylic acid ethyl ester 
• 459-57-4 4-fluorobenzaldehyde 
• 141-97-9 ethyl acetoacetate 
• 1091909-58-8 ethyl 4-(4-fluorophenyl)-1,2-dihydro-6-methyl-2-oxopyrimidine-5-carboxylate 
• 5937-24-6 ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 

Downstream Products

• 1448992-24-2 ethyl 4-(4-fluorophenyl)-2-(4-((7-chloroquinolin-4-yl)amino)butylamino)-6-methylpyrimidine-5-carboxylate 

Relevant articles and documents

Structure elaboration of isoniazid: synthesis, in silico molecular docking and antimycobacterial activity of isoniazid–pyrimidine conjugates

Abstract: Designing small molecule-based new drug candidates through structure modulation of the existing drugs has drawn considerable attention in view of inevitable emergence of resistance. A new series of isoniazid–pyrimidine conjugates were synthesize

Pyrimidine-5-carboxylic acid ester compound and its preparation method and application

The invention discloses a pyrimidine-5-formate compound as well as a preparation method and an application thereof. The pyrimidine-5-formate compound is shown as a formula 1, wherein in the formula 1, R1 is methyl, ethyl, propyl, n-butyl, isopropyl, tert-butyl, cyclopentyl, cyclohexyl or substituted phenyl or benzyl. The synthetic route comprises the following steps: reacting urea, ethyl acetoacetate and p-fluorobenzaldehyde to obtain 4-(4-fluorophenyl)-6-methyl-2-carbonyl-1,2,3,4-tetrahydropyrimidine-5-ethyl formate; reacting to obtain 4-(4-fluorophenyl)-2-hydroxy-6-methylpyrimidine-5-ethyl formate under the action of an oxidizing agent; reacting the 4-(4-fluorophenyl)-2-hydroxy-6-methylpyrimidine-5-ethyl formate with a chlorinated reagent to obtain 2-chloro-4-(4-fluorophenyl)-6-methylpyrimidine-5-ethyl formate; and finally, reacting with substituted amine to obtain the target compound. The pyrimidine-5-formate compound can effectively prevent and control broad leaf weeds and is safe to graminaceous crops.

Synthesis of 4-aminoquinoline - Pyrimidine hybrids as potent antimalarials and their mode of action studies

One of the most viable options to tackle the growing resistance to the antimalarial drugs such as artemisinin is to resort to synthetic drugs. The multi-target strategy involving the use of hybrid drugs has shown promise. In line with this, new hybrids of