144942-89-2 Usage
Description
Amino-PEG1-acid is a PEG (polyethylene glycol) linker that features an amino group (NH2) and a terminal carboxylic acid (CO2H). The NH2 group is reactive with carboxylic acids in the presence of a coupling reagent like EDC, or it can directly form a stable amide bond with NHS esters.
Uses
Used in Pharmaceutical Industry:
Amino-PEG1-acid is used as a molecular linker for enhancing the solubility and stability of drugs. Its ability to form stable amide bonds with carboxylic acids and NHS esters allows for the creation of prodrugs or drug conjugates with improved pharmacokinetic properties.
Used in Bioconjugation:
Amino-PEG1-acid is used as a bioconjugation agent to attach biologically active molecules, such as peptides, proteins, or other therapeutic agents, to a PEG backbone. This increases the molecular weight and hydrophilicity of the conjugate, which can improve its circulation time and reduce immunogenicity.
Used in Drug Delivery Systems:
Amino-PEG1-acid is used as a component in the design of drug delivery systems, such as nanoparticles or liposomes. The PEG linker can provide stealth properties, reducing the recognition and clearance by the immune system, while the reactive amino group allows for the attachment of therapeutic agents or targeting moieties.
Used in Diagnostics:
Amino-PEG1-acid can be used in the development of diagnostic tools, such as imaging agents or biosensors, by attaching specific recognition elements or signaling molecules to the PEG backbone, enhancing their stability and bioavailability in biological systems.
Check Digit Verification of cas no
The CAS Registry Mumber 144942-89-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,9,4 and 2 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 144942-89:
(8*1)+(7*4)+(6*4)+(5*9)+(4*4)+(3*2)+(2*8)+(1*9)=152
152 % 10 = 2
So 144942-89-2 is a valid CAS Registry Number.
144942-89-2Relevant articles and documents
Poly(vinyl ester) Polymers for In Vivo Nucleic Acid Delivery
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Paragraph 0170, (2015/10/28)
The present invention is directed membrane active poly(vinyl ester) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cells in vivo. RNAi polynucleotides are conjugated to the poly(vinyl ester) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(vinyl ester) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness.
