1450-76-6

Basic information

• Product Name: 2'-HYDROXY-5'-NITROACETOPHENONE
• Synonyms: 2'-HYDROXY-5'-NITROACETOPHENONE;2-HYDROXY-5-NITROACETOPHENONE;1-(2-HYDROXY-5-NITROPHENYL)ETHANONE;1-(5-Nitro-2-hydroxyphenyl)ethanone;Nsc64461;1-(2-hydroxy-5-nitrophenyl)ethan-1-one;2'-Hydroxy-5'-nitroacetophenone 97%;Ethanone, 1-(2-hydroxy-5-nitrophenyl)-
• CAS NO: 1450-76-6
• Molecular Formula: C₈H₇NO₄
• Molecular Weight: 181.14548
• Product Categories: Benzene series;Alcohols and Derivatives;Carbonyl Compounds;Aromatic Acetophenones & Derivatives (substituted);C7 to C8;Carbonyl Compounds;Ketones
• Mol File: 1450-76-6.mol
• Article Data: 29

Chemical Properties

• Melting Point: 100-104 °C(lit.)
• Boiling Point: 285.5 °C at 760 mmHg
• Flash Point: 126 °C
• Appearance: /
• Density: 1.38 g/cm³
• Vapor Pressure: 0.00163mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Methanol (Slightly, Heated)
• PKA: 7.27±0.22(Predicted)
• CAS DataBase Reference: 2'-HYDROXY-5'-NITROACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-HYDROXY-5'-NITROACETOPHENONE(1450-76-6)
• EPA Substance Registry System: 2'-HYDROXY-5'-NITROACETOPHENONE(1450-76-6)

Safety Data

• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 1450-76-6(Hazardous Substances Data)

Usage

Description

2'-HYDROXY-5'-NITROACETOPHENONE is an organic compound with the molecular formula C8H7NO3. It is characterized by the presence of a hydroxyl group at the 2' position and a nitro group at the 5' position on an acetophenone backbone. 2'-HYDROXY-5'-NITROACETOPHENONE has potential applications in various fields due to its unique chemical structure and properties.

Uses

Used in Pharmaceutical Industry:
2'-HYDROXY-5'-NITROACETOPHENONE is used as a potential inhibitor of platelet aggregation for the prevention and treatment of blood clot-related disorders. Its ability to inhibit platelet aggregation makes it a promising candidate for the development of anti-thrombotic drugs, which can help in reducing the risk of heart attacks, strokes, and other cardiovascular diseases.

InChI:InChI=1/C8H7NO4/c1-5(10)7-4-6(9(12)13)2-3-8(7)11/h2-4,11H,1H3/p-1

Upstream product

• 118-93-4 o-hydroxyacetophenone 
• 10320-42-0 2-Chloro-5-nitropyrimidine 
• 123-54-6 acetylacetone 
• 100-02-7 4-nitro-phenol 
• 64-19-7 acetic acid 
• 61941-46-6 1-(2-methoxy-5-nitro-phenyl)-ethanone 
• 75-30-9 2-iodo-propane 
• 189814-42-4 2-isopropoxy-5-nitroacetophenone 
• 491-38-3 1-benzopyran-4(4H)-one 
• 100-17-4 para-methoxynitrobenzene 
• 75-36-5 acetyl chloride 
• 14080-32-1 5-nitropyrimidine 
• 68541-87-7 1-(2-methyl-5-nitropyridin-3-yl)ethanone 
• 14001-69-5 5-nitro-2-methoxypyrimidine 

Downstream Products

• 23398-90-5 2'-hydroxy-3,4-methylenedioxy-5'-nitro-trans-chalcone 
• 133043-99-9 5-bromo-2'-hydroxy-2-methoxy-5'-nitro-trans-chalcone 
• 49619-68-3 1-(5-(dimethylamino)-2-hydroxyphenyl)ethan-1-one 
• 96-97-9 5-nitrosalicylic acid 
• 857842-84-3 2-ethoxy-5-nitroacetophenone 
• 1138464-58-0 C₁₅H₁₇NO₄ 
• 1262304-91-5 (E)-N'-[1-(2-hydroxy-5-nitrophenyl)ethyliden]isonicotinoyl-hydrazide 
• 1338924-59-6 2-bromo-N-[3-methyl-2-(3,4,5-trimethoxybenzoyl)-1-benzo[b]furan-5-yl]acrylamide 
• 1338924-43-8 (5-amino-3-methylbenzo[b]furan-2-yl)(3,4,5-trimethoxyphenyl)-methanone 
• 1338924-31-4 C₁₉H₁₇NO₇ 
• 1407486-84-3 2-acetyl-4-nitrophenyl methanesulfonate 
• 329722-31-8 1-[5-nitro-2-(oxiran-2-ylmethoxy)phenyl]ethan-1-one 
• 329722-32-9 1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-nitrophenyl}ethan-1-one 
• 56980-94-0 1-{5-amino-2-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl}ethan-1-one 

Relevant articles and documents

A new and improved process for celiprolol hydrochloride

Celiprolol hydrochloride, a β-blocker drug, has been synthesized by a new approach. How this new process offers distinctive advantages over the existing one will be described.

Sigma Complexes in the Pyrimidine Series. 6. Reaction of 5-Nitro-2-methoxy- and 5-Nitro-4,6-dimethoxypyrimidines with the Acetylacetone Carbanion

Depending on the reaction conditions, the reaction of 5-nitro-2-methoxy- and 5-nitro-4,6-dimethoxypyrimidines with acetylacetone carbanion gives potassium salts of 5-nitrodiacetylmethylenepyrimidines or, as a result of recyclization of the pyrimidine ring, 5-nitro-2-hydroxyacetophenone.

A kind of two-thiazoline ketone compounds and pharmaceutical compositions thereof and use thereof (by machine translation)

The invention provides general formula (I) indicated by the thiazoline ketone compounds and pharmaceutical compositions thereof and use thereof. The compounds can be combined with the bromodomain domain of the protein, thereby adjusting the downstream signal path, to play a particular function, can be used for treating the relevant domain protein in the bromodomain of various diseases. Such compounds can be interference has Brd4 bromodomain domain with the acetylated histone binding, and then lower the oncogene c - the ventilating cabins and its related target gene transcription, so that it may be effective for treating the tumor. (by machine translation)

Design, synthesis and docking studies of novel thienopyrimidine derivatives bearing chromone moiety as mTOR/PI3Kα inhibitors

Two series of thienopyrimidine derivatives (10a-k, 16a-j) bearing chromone moiety were designed and synthesized. All the compounds were evaluated for inhibitory activity against mTOR kinase at a concentration of 10uM. Four selected compounds were further evaluated for the IC50 values against mTOR kinase, PI3Kα kinase and two cancer cell lines. Some of the target compounds exhibited moderate to excellent mTOR/PI3Kα kinase inhibitory activity and cytotoxicity. The most promising compound 16i showed good inhibitory activity against mTOR/PI3Kα kinase and good antitumor potency for H460 and PC-3 cell lines with IC50 values of 0.16 ± 0.03 μM, 2.35 ± 0.19 μM, 1.20 ± 0.23 μM and 0.85 ± 0.04 μM, which were 8.6, >5, 7.9 and 19.1 times more active than compound I (1.37 ± 0.07 μM, >10 μM, 9.52 ± 0.29 μM, 16.27 ± 0.54 μM), respectively. Structure-activity relationships (SARs) and docking studies indicated that the chromone moiety is necessary for the potent antitumor activity and cytotoxicity of these compounds. Substitution of the chromone moiety at the 6-position has a significant impact to the inhibitory activity, in particular a carboxylic acid group, produced the best potency.