14510-37-3

Basic information

• Product Name: Acetyltropylic chloride
• Synonyms: Tropoyl chloride acetate;alpha-((Acetyloxy)methyl)benzeneacetyl chloride;Acetyltropoyl chloride;acetyltropylic chloride;Acetyltropopl chloride;α-[(Acetyloxy)methyl]benzeneacetyl chloride;Benzeneacetyl chloride, a-[(acetyloxy)Methyl]-;TropicaMide InterMediate
• CAS NO: 14510-37-3
• Molecular Formula: C₁₁H₁₁ClO₃
• Molecular Weight: 226.66
• EINECS: 236-410-3
• Mol File: 14510-37-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 319°C
• Flash Point: 131°C
• Appearance: /
• Density: 1.228
• CAS DataBase Reference: Acetyltropylic chloride(CAS DataBase Reference)
• NIST Chemistry Reference: Acetyltropylic chloride(14510-37-3)
• EPA Substance Registry System: Acetyltropylic chloride(14510-37-3)

Safety Data

• Hazardous Substances Data: 14510-37-3(Hazardous Substances Data)

Usage

General Description

Acetyltropylic chloride, also known as 2-Chloro-2-methylbutyryl chloride, is a chemical compound with the formula C6H11ClO. It is a colorless or pale yellow liquid with a pungent odor and is highly reactive. Acetyltropylic chloride is commonly used in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. It is also utilized as an intermediate in the manufacture of dyes, paints, and polymers. Acetyltropylic chloride is highly corrosive and can cause severe skin and eye irritation, as well as respiratory issues if inhaled. Proper safety measures should be observed when handling acetyltropylic chloride.

Upstream product

• 529-64-6 Tropic acid 
• 75-36-5 acetyl chloride 
• 37504-67-9 α-[(acetyloxy)methyl]benzeneacetic acid 
• 108-24-7 acetic anhydride 

Downstream Products

• 101112-51-0 tropic acid-([4]pyridylmethyl-amide) 
• 109066-24-2 3endo-atropoyloxy-tropane-6exo,7exo-diol 
• 1508-75-4 tropicamide 
• 101785-34-6 tropic acid-(isopropyl-[4]pyridylmethyl-amide) 
• 109555-56-8 tropic acid-(propyl-[4]pyridylmethyl-amide) 
• 51-34-3 (+/-)-scopolamine 
• 51-55-8 Atropine 
• 35598-48-2 3-hydroxy-2-phenyl-propionic acid 8ξ-cyclohexyl-8ξ-oxo-8λ⁵-phospha-bicyclo[3.2.1]oct-3exo-yl ester 
• 35598-48-2 3-hydroxy-2-phenyl-propionic acid 8ξ-cyclohexyl-8ξ-oxo-8λ⁵-phospha-bicyclo[3.2.1]oct-3endo-yl ester 
• 35598-50-6 3-hydroxy-2-phenyl-propionic acid 8-cyclohexyl-8-phospha-bicyclo[3.2.1]oct-3exo-yl ester 
• 35598-51-7 3-hydroxy-2-phenyl-propionic acid 8-cyclohexyl-8-phospha-bicyclo[3.2.1]oct-3endo-yl ester 
• 22235-81-0 (1R,3R,5S)-3'-hydroxy-2'-phenylpropionic acid 8-isopropyl-8-azabicyclo[3.2.1]oct-3-yl ester 

Relevant articles and documents

Synthesis method of atropine and atropine sulfate

The invention provides a synthesis method of atropine and atropine sulfate, which comprises the following steps: carrying out acetylation reaction on tropine acid to form acetyl tropine acid, reactingthe acetyl tropine acid with a chlorination reagent to form acyl chloride, reacting the acyl chloride with tropine alcohol, removing acetyl to obtain atropine, and salifying atropine and sulfuric acid to obtain atropine sulfate. The whole synthesis process can be completed by adopting a one-pot reaction, additional steps for completing the process by isolating intermediates are avoided, the reaction conditions are mild, the steps are simple, the yield is high, the purity is high, and the method is suitable for large-scale industrial production.

Total Synthesis of (±)-Scopolamine: Challenges of the Tropane Ring

Scopolamine was synthesized using 6,7-dehydrotropine as a key intermediate. Rhodium-catalyzed [4 + 3] cycloaddition chemistry and a modified Robinson-Sch?pf reaction were each independently evaluated for their utility in constructing the tropane core. Both synthetic approaches gave comparable overall yields.

Synthesis of some piperidyl esters of acetyltropic and diphenylacetic acid

-