145131-34-6

Basic information

• Product Name: 1-[2,6-bis(1-methylethyl)phenyl]-3-[2-butyl-2-(1-methyl-1H-indol-3-yl)hexyl]urea
• CAS NO: 145131-34-6
• Molecular Formula: C₃₂H₄₇N₃O
• Molecular Weight: 489.7351
• Mol File: 145131-34-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 596.3°C at 760 mmHg
• Flash Point: 314.4°C
• Density: 1.02g/cm³
• Vapor Pressure: 3.48E-14mmHg at 25°C
• Refractive Index: 1.55
• CAS DataBase Reference: 1-[2,6-bis(1-methylethyl)phenyl]-3-[2-butyl-2-(1-methyl-1H-indol-3-yl)hexyl]urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2,6-bis(1-methylethyl)phenyl]-3-[2-butyl-2-(1-methyl-1H-indol-3-yl)hexyl]urea(145131-34-6)
• EPA Substance Registry System: 1-[2,6-bis(1-methylethyl)phenyl]-3-[2-butyl-2-(1-methyl-1H-indol-3-yl)hexyl]urea(145131-34-6)

Safety Data

• Hazardous Substances Data: 145131-34-6(Hazardous Substances Data)

Usage

Class

Phenylureas
It belongs to a class of organic compounds that contain a urea group attached to a phenyl ring.

Appearance

White solid
The compound is a white, solid substance at room temperature.

Molecular weight

539.823 g/mol
The molecular weight of the compound is 539.823 grams per mole.

Application

Medicinal chemistry and pharmaceuticals
It is used in the field of medicinal chemistry and pharmaceuticals for potential applications in treating various medical conditions.

Synthesis

Of interest to researchers in organic chemistry and drug development
The synthesis and properties of this compound are of interest to researchers working in the fields of organic chemistry and drug development.

Potential applications

Treatment of various medical conditions
The compound may have potential applications in the treatment of various medical conditions, although specific conditions are not mentioned in the provided material.

Upstream product

• 1026067-54-8 2-Butyl-2-(1-methyl-1H-indol-3-yl)-hexanenitrile 
• 51584-17-9 1-methyl-1H-indole-3-acetonitrile 
• 771-51-7 indole-3-acetonitrile 
• 28178-42-9 2,6-diisopropylphenyl isocyanate 
• 1026413-04-6 2-Butyl-2-(1-methyl-1H-indol-3-yl)-hexylamine 

Relevant articles and documents

New indole derivatives as ACAT inhibitors: Synthesis and structure-activity relationships

A series of ureas containing the indole group were synthesized and assessed for their ability to inhibit arterial and intestinal ACAT and to lower plasma total cholesterol in a cholesterol-fed rat model. The structural modulations carried out in this series led to compounds which proved to be very active in both the inhibition of aortic ACAT in vitro and the inhibition of rat cholesterol intestinal absorption in vivo. Several compounds from this series exhibit a remarkable hypocholesterolaemic effect with ED25 less than 0.1 mg/kg po.