145162-47-6

Basic information

• Product Name: 1-benzyl-1H-pyrazole-2-oxide
• Synonyms: 1-benzyl-1H-pyrazole-2-oxide
• CAS NO: 145162-47-6
• Molecular Weight: 174.202
• Mol File: 145162-47-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-benzyl-1H-pyrazole-2-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-1H-pyrazole-2-oxide(145162-47-6)
• EPA Substance Registry System: 1-benzyl-1H-pyrazole-2-oxide(145162-47-6)

Safety Data

• Hazardous Substances Data: 145162-47-6(Hazardous Substances Data)

Upstream product

• 10199-67-4 1-benzylpyrazole 
• 1197-51-9 N-propargylbenzylamine 
• 21932-11-6 1,5-dibenzyl-1,5-diazapenta-1,3-diene 
• 100-39-0 benzyl bromide 
• 81945-73-5 1H-pyrazol-1-ol 

Downstream Products

• 50877-39-9 1-benzyl-5-chloropyrazole 
• 145162-58-9 2-benzyl-3-bromo-4-nitropyrazole 1-oxide 
• 145162-55-6 2-benzyl-3-chloro-4-nitropyrazole 1-oxide 
• 145162-68-1 1-benzyl-5-bromo-3-hydroxy-4-nitropyrazole 
• 145162-67-0 1-benzyl-3-hydroxy-4-nitro-5-chloropyrazole 
• 145162-59-0 2-benzyl-3,4-dibromopyrazole 1-oxide 
• 145162-57-8 2-benzyl-4-bromo-3-chloropyrazole 1-oxide 
• 145162-66-9 2-benzyl-4,5-dibromopyrazole 1-oxide 
• 145162-69-2 2-benzyl-3-nitro-1H-pyrazole 
• 145162-65-8 2-benzyl-4-bromopyrazole 1-oxide 
• 145162-71-6 3-nitro-2-(4-nitrobenzyl)pyrazole 1-oxide 
• 145162-64-7 3,5-dinitro-2-(4-nitrobenzyl)pyrazole 1-oxide 
• 145162-61-4 3,4,5-tribromo-2-benzylpyrazole 1-oxide 
• 145162-52-3 2-benzyl-3-nitropyrazole 1-oxide 

Relevant articles and documents

Regioselective Synthesis of C3-Hydroxyarylated Pyrazoles

Pyrazoles are ubiquitous structures in medicinal chemistry. We report the first regioselective route to C3-hydroxyarylated pyrazoles obtained through reaction of pyrazole N-oxides with arynes using mild conditions. Importantly, this method does not requir

Synthesis of 4-hydroxylamino-1-azabuta-1,3-dienes and their cyclization to 2-substituted pyrazole 1-oxides

2-Aromatic or 2-aliphatic substituted pyrazole 1-oxides with substituents at the 3-, 4- or 5-position have been prepared from β-dicarbonyl compounds or ketones.The β-dicarbonyl compounds were treated with p-toluidine to give 1,5-di-p-tolyl-1,5-diazapenta-1,3-dienium salts in which the p-tolyimino groups can be converted into alkylimino groups by treatment with aliphatic amine.Subsequent deprotonation and treatment with O-tert-butyldimethylsilylhydroxylamine produced 4-arylamino- or 4-alkylamino-1-tert-butyldimethylsilyloxy-1-azabuta-1,3-diene.The tautomeric structure, the configuration and the conformation of the dienes were elucidated by 1H and 13C NMR spectroscopy.Oxidation of the alkylamino-1-tert-butyldimethylsilyloxy-1-azabuta-1,3-dienes with copper(II) ions led to cyclization with formation of pyrazole 1-oxides.These could be prepared by oxidation of 3-amino oximes obtained from ketones through aminoalkylation at the α-position and treatment with hydroxyammonium chloride.If 1,5-diaryl-1,5-diazapenta-1,3-diene was treated with O-(p-tolylsulfonyl)hydroxylamine spontaneous cyclization occurred to give 1-(p-tolyl)pyrazole.

2-Substituted Pyrazole 1-Oxides. Preparation and Reaction with Electrophilic Reagents

1-Substituted pyrazoles have been oxidized by peracids to 2-substituted pyrazole 1-oxides.This leads to a change in reactivity towards electrophilic attack. 2-Benzylpyrazole 1-oxide is brominated, chlorinated, and nitrated selectively at C-3.The 3-halo-su