1452261-76-5

Basic information

• Product Name: (2E,4E)-ethyl 5-(2,4-difluorophenylsulfonyl)penta-2,4-dienoate
• Synonyms: (2E,4E)-ethyl 5-(2,4-difluorophenylsulfonyl)penta-2,4-dienoate
• CAS NO: 1452261-76-5
• Molecular Weight: 302.299
• Mol File: 1452261-76-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2E,4E)-ethyl 5-(2,4-difluorophenylsulfonyl)penta-2,4-dienoate(CAS DataBase Reference)
• NIST Chemistry Reference: (2E,4E)-ethyl 5-(2,4-difluorophenylsulfonyl)penta-2,4-dienoate(1452261-76-5)
• EPA Substance Registry System: (2E,4E)-ethyl 5-(2,4-difluorophenylsulfonyl)penta-2,4-dienoate(1452261-76-5)

Safety Data

• Hazardous Substances Data: 1452261-76-5(Hazardous Substances Data)

Upstream product

• 1452261-49-2 bis((2,4-difluorophenyl)thio)methane 
• 1996-44-7 2,4-difluorothiophenol 
• 37746-78-4 4-bromo-trans-crotonic acid ethyl ester 
• 1933-73-9 bis(2,4-difluorophenylsulfonyl)methane 

Relevant articles and documents

A one-pot stereoselective synthesis of electron-deficient 4-substituted (E, E)-1-arylsulfonylbuta-1,3-dienes and their chemoselective [3+2] cycloaddition with azomethine ylides - A simple synthesis of 1,3,4-trisubstituted pyrrolidines and pyrroles

A simple and efficient method for the synthesis of (E,E)-1-(arylsulfonyl) buta-1,3-dienes bearing electron-withdrawing substituents like cyano and ethoxycarbonyl at position 4, involving a one-pot alkylation of bis(phenylsulfonyl)methane with trans-ethyl 4-bromocrotonate/trans-4- bromocrotononitrile, and elimination of arylsulfinic acid, is described. These dienes undergo facile mono [3+2] cycloaddition with azomethine ylides chemoselectivity to furnish functionalized 1,3,4-trisubstituted pyrrolidines. Oxidation of these cycloadduct with MnO2·SiO2 under mild conditions provides 1,3,4-trisubstituted pyrroles. Georg Thieme Verlag Stuttgart. New York.