145240-42-2

Basic information

• Product Name: 2',4'-DIFLUORO-2-HYDROXYACETOPHENONE
• Synonyms: RARECHEM AL BD 1384;2-HYDROXY-1-(2,4-DIFLUOROPHENYL)ETHANONE;2',4'-DIFLUORO-2-HYDROXYACETOPHENONE
• CAS NO: 145240-42-2
• Molecular Formula: C₈H₆F₂O₂
• Molecular Weight: 172.13
• Mol File: 145240-42-2.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2',4'-DIFLUORO-2-HYDROXYACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2',4'-DIFLUORO-2-HYDROXYACETOPHENONE(145240-42-2)
• EPA Substance Registry System: 2',4'-DIFLUORO-2-HYDROXYACETOPHENONE(145240-42-2)

Safety Data

• Hazardous Substances Data: 145240-42-2(Hazardous Substances Data)

Usage

General Description

2',4'-Difluoro-2-hydroxyacetophenone, also known as diflunisal, is a chemical compound with the formula C8H6F2O2. It is a white crystalline solid that is commonly used as a nonsteroidal anti-inflammatory drug (NSAID), primarily for the treatment of arthritis and other inflammatory conditions. Diflunisal works by inhibiting the production of prostaglandins, which are responsible for causing pain and inflammation in the body. It is also used as an analgesic and antipyretic, providing relief from pain and reducing fever. Diflunisal is usually administered orally and has a long half-life, allowing for less frequent dosing than other NSAIDs. It is considered effective and well-tolerated, making it a popular choice for long-term pain management.

Upstream product

• 50-00-0 formaldehyd 
• 1550-35-2 2,4-difluorobenzaldehyde 
• 67-56-1 methanol 
• 364-83-0 2',4'-difluoroacetophenone 
• 102429-07-2 2-bromo-2',4'-difluoroacetophenone 
• 51336-94-8 2-chloro-1-(2,4-dichlorophenyl)ethanone 
• 122263-03-0 2-Acetyloxy-1-(2,4-difluorophenyl)ethanone 

Downstream Products

• 182482-28-6 2-(tert-Butyl-dimethyl-silanyloxy)-1-(2,4-difluoro-phenyl)-ethanone 
• 1610616-75-5 (R)-2-(2,4-difluorophenyl)but-3-ene-1,2-diol 
• 1610617-00-9 (R)-4-(2,4-difluorophenyl)-4-vinyl-1,3-dioxolane 
• 1610616-81-3 4-(2,4-difluorophenyl)-4-vinyl-1,3-dioxolan-2-one 
• 1202852-66-1 2-(2,4-difluorophenyl)but-3-ene-1,2-diol 
• 123364-90-9 (1R,2S)-2-(2,4-Difluoro-phenyl)-1-methylsulfanyl-1,3-bis-[1,2,4]triazol-1-yl-propan-2-ol 
• 123364-90-9 (1S,2S)-2-(2,4-Difluoro-phenyl)-1-methylsulfanyl-1,3-bis-[1,2,4]triazol-1-yl-propan-2-ol 
• 123365-34-4 (1R,2S)-2-(2,4-Difluoro-phenyl)-3-methoxymethoxy-1-methylsulfanyl-1-[1,2,4]triazol-1-yl-propan-2-ol 
• 123365-34-4 (1S,2S)-2-(2,4-Difluoro-phenyl)-3-methoxymethoxy-1-methylsulfanyl-1-[1,2,4]triazol-1-yl-propan-2-ol 
• 123365-41-3 (2S,3R)-2-(2,4-Difluoro-phenyl)-3-methylsulfanyl-3-[1,2,4]triazol-1-yl-propane-1,2-diol 
• 123365-41-3 (2S,3S)-2-(2,4-Difluoro-phenyl)-3-methylsulfanyl-3-[1,2,4]triazol-1-yl-propane-1,2-diol 
• 123365-49-1 1-{(R)-[(R)-2-(2,4-Difluoro-phenyl)-oxiranyl]-methylsulfanyl-methyl}-1H-[1,2,4]triazole 
• 123365-49-1 1-{(S)-[(R)-2-(2,4-Difluoro-phenyl)-oxiranyl]-methylsulfanyl-methyl}-1H-[1,2,4]triazole 
• 217650-34-5 N-[1-(2,4-difluoro-phenyl)-2-methoxymethoxy-vinyl]-acetamide 

Relevant articles and documents

Chiral Bidentate Phosphoramidite-Pd Catalyzed Asymmetric Decarboxylative Dipolar Cycloaddition for Multistereogenic Tetrahydrofurans with Cyclic N-Sulfonyl Ketimine Moieties

An asymmetric [3 + 2] cycloaddition of vinyl ethylenecarbonates (VECs) and (E)-3-arylvinyl substituted benzo[d] isothiazole 1,1-dioxides has been developed using the Pd complex of a bidentate phosphoramidite (Me-BIPAM) as the catalyst, providing a wide variety of chiral multistereogenic vinyltetrahydrofurans in good yields with excellent diastereo- and enantioselectivities (up to >20:1 dr, 99% ee).

Vinylethylene Carbonates as α,β-Unsaturated Aldehyde Surrogates for Regioselective [3 + 3] Cycloaddition

Herein, we report a novel stepwise addition-controlled ring size method, to access tetrahydropyrimidines through an operationally simple [3 + 3] cycloaddition of vinylethylene carbonates with triazinanes. Interestingly, we could also use this method for a [3 + 3] oxidative cycloaddition, which allows the facile synthesis of polysubstituted terphenyls under mild conditions. Mechanistic studies suggest that vinylethylene carbonates could generate α,β-unsaturated aldehydes as 3-carbon synthons for cycloaddition via a combination process of Pd-catalyzed decarboxylation and β-H elimination.

Divergent synthesis of N-heterocycles by Pd-catalyzed controllable cyclization of vinylethylene carbonates

Here, we report a palladium-catalyzed controllable cyclization of vinyl ethylene carbonates that proceeds through formal migration [2+3] and [5+2] cycloadditions, respectively, under mild conditions. The transformation described here affords a series of synthetically versatile 5,7-membered N-heterocycles which are found in natural products and pharmaceuticals with biological and medicinal properties.