145307-22-8Relevant articles and documents
Gram Scale Syntheses of (-)-Incarvillateine and Its Analogs. Discovery of Potent Analgesics for Neuropathic Pain
Huang, Bin,Zhang, Fengying,Yu, Gang,Song, Yan,Wang, Xintong,Wang, Meiliang,Gong, Zehui,Su, Ruibin,Jia, Yanxing
, p. 3953 - 3963 (2016)
(-)-Incarvillateine (INCA) is the major antinociceptive component of Incarvillea sinensis, which has been used to treat rheumatism and relieve pain in traditional Chinese medicine. We have developed a concise and general synthetic approach for INCA, which
Total synthesis of (-)-incarvilline
Ichikawa, Masaya,Aoyagi, Sakae,Kibayashi, Chihiro
, p. 2327 - 2329 (2007/10/03)
An enantioselective synthesis of (-)-incarvilline is presented, employing a three-component coupling reaction and an intramolecular enone-olefin [2+2] photocycloaddition followed by a SmI2-induced cyclobutane ring-opening reaction.