145328-30-9Relevant articles and documents
A Rapid and Highly Efficient Method for the Synthesis of Benzofulvenes via CsOH-Catalyzed Condensation of Indene and Aldehydes
Yi, Rongnan,Chen, Jinyang,Wang, Xueyan,Liang, Zhiwu,Xu, Xinhua
, p. 1347 - 1351 (2018)
A fast condensation of indene with a wide range of aldehydes catalyzed by cesium hydroxide monohydrate (CsOH·H2O) for the synthesis of benzofulvenes with good to excellent yields was demonstrated. The condensation can be completed within a few minutes under room temperature and air atmosphere without the use of special ligands or phase-transfer catalysts. In addition, the ratio of indene to aldehydes played an important role in this reaction. The single condensation products 3 can be obtained as main products with a ratio of 1.2:1, whereas the double condensation products 4 can be obtained by changing the ratio to 1:2.2. This protocol provides an efficient, simple and general method for the synthesis of benzofulvenes 3 and double condensation products 4, which are important intermediates in the synthesis of numerous drugs and natural products.