1453849-05-2

Basic information

• Product Name: 1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one
• CAS NO: 1453849-05-2
• Molecular Weight: 444.893
• Mol File: 1453849-05-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one(1453849-05-2)
• EPA Substance Registry System: 1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one(1453849-05-2)

Safety Data

• Hazardous Substances Data: 1453849-05-2(Hazardous Substances Data)

Upstream product

• 1453854-80-2 1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4-yl)pyridin-2(1H)-one 
• 1453851-65-4 2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl methanesulfonate 
• 1453852-02-2 2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethanol 
• 170793-00-7 4-chloro-3-fluorophenylmagnesium bromide 
• 401815-98-3 2-fluoropyridin-4-ylboronic acid 
• 1453851-57-4 4-(2-(methylthio)pyrimidin-4-yl)pyridin-2(1H)-one 
• 1453851-73-4 4-(2-fluoropyridin-4-yl)-2-(methylthio)pyrimidine 

Relevant articles and documents

Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2

Using structure-based design, a novel series of pyridone ERK1/2 inhibitors was developed. Optimization led to the identification of (S)-14k, a potent, selective, and orally bioavailable agent that inhibited tumor growth in mouse xenograft models. On the basis of its in vivo efficacy and preliminary safety profiles, (S)-14k was selected for further preclinical evaluation.