1453869-57-2

Basic information

• Product Name: diphenyl N-(5-chloro-2-phenoxyphenylcarbamimido-1-yl)phosphoramidate
• Synonyms: diphenyl N-(5-chloro-2-phenoxyphenylcarbamimido-1-yl)phosphoramidate
• CAS NO: 1453869-57-2
• Molecular Weight: 493.886
• Mol File: 1453869-57-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: diphenyl N-(5-chloro-2-phenoxyphenylcarbamimido-1-yl)phosphoramidate(CAS DataBase Reference)
• NIST Chemistry Reference: diphenyl N-(5-chloro-2-phenoxyphenylcarbamimido-1-yl)phosphoramidate(1453869-57-2)
• EPA Substance Registry System: diphenyl N-(5-chloro-2-phenoxyphenylcarbamimido-1-yl)phosphoramidate(1453869-57-2)

Safety Data

• Hazardous Substances Data: 1453869-57-2(Hazardous Substances Data)

Upstream product

• 2524-64-3 chlorophosphoric acid diphenyl ester 
• 93-67-4 5-chloro-2-phenoxyaniline 

Relevant articles and documents

Synthesis and biological activity of novel diphenyl N - Substituted Carbamimidoylphosphoramidate derivatives

An efficient synthesis of a series of novel diphenyl N-substituted carbamimidoyl phosphoramidate derivatives was accomplished in two steps. Diphenyl phosphorochloridate (1) was reacted with cyanamide (2) in the presence of 1,4-dimethylpiperazine as a base in THF at 50-55 °C to form an intermediate, diphenyl cyanophosphoramidate (3). Subsequently 3 was reacted with various aromatic/heterocyclic amines (4) in the presence of 1,4-dimethyl piperazine as a base at 55-60 °C to form the corresponding title compounds 5(a-k). The title compounds were tested for antiviral activity against Tobacco mosaic virus (TMV) in vitro, antibacterial and antifungal activities at two different concentrations of 50 and 100 μg/mL. The title compounds exhibited good antiviral and antimicrobial activities when compared to the standards.