1454-65-5

Basic information

• Product Name: (4-CHLOROPHENYL)ACETONE OXIME
• Synonyms: (4-CHLOROPHENYL)ACETONE OXIME;2-PROPANONE, 1-(4-CHLOROPHENYL)-, OXIME
• CAS NO: 1454-65-5
• Molecular Formula: C₉H₁₀ClNO
• Molecular Weight: 183.63
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
• Mol File: 1454-65-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4-CHLOROPHENYL)ACETONE OXIME(CAS DataBase Reference)
• NIST Chemistry Reference: (4-CHLOROPHENYL)ACETONE OXIME(1454-65-5)
• EPA Substance Registry System: (4-CHLOROPHENYL)ACETONE OXIME(1454-65-5)

Safety Data

• Hazardous Substances Data: 1454-65-5(Hazardous Substances Data)

Usage

General Description

(4-Chlorophenyl)acetone oxime is a chemical compound with the formula C8H9NOCl. It is an oxime derived from (4-chlorophenyl)acetone, which is commonly used in the synthesis of pharmaceuticals and other organic compounds. (4-Chlorophenyl)acetone oxime has been studied for its potential as a cholinesterase reactivator, which could have applications for counteracting the effects of nerve agents and other chemical weapons. It is also used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. Additionally, it is known to have antioxidant properties, making it useful for various industrial applications.

Upstream product

• 25026-34-0 4-chlorophenacetyl chloride 
• 5586-88-9 1-(4-chlorophenyl)propan-2-one 
• 1163136-86-4 1-chloro-4-(2-nitro-1(Z)-propenyl)benzene 
• 710-20-3 1-chloro-4-(2-nitropropenyl)benzene 

Downstream Products

• 1061288-55-8 3β-(4-methylphenyl)-2β-[3'-(4-chlorobenzyl)isoxazol-5-yl]tropane 
• 1061288-74-1 3β-(4-methylphenyl)-2β-[3'-methyl-4'-(4-chlorophenyl)isoxazol-5-yl]tropane 
• 1061288-52-5 3β-(4-chlorophenyl)-2β-[3'-(4-chlorobenzyl)isoxazol-5-yl]tropane 
• 1061288-71-8 3β-(4-chlorophenyl)-2β-[3'-methyl-4'-(4-chlorophenyl)isoxazol-5-yl]tropane 
• 63-93-4 N-hydroxy-1-methyl-2-(4-chlorophenyl)ethanamine 
• 64-12-0 p-Chloroamphetamine 
• 80605-47-6 p-Chlorbenzylmethylketonoximpikrat 
• 1262155-46-3 C₁₉H₁₆ClNO₃S 

Relevant articles and documents

Modular 2,3-diaryl-2: H -azirine synthesis from ketoxime acetates via Cs2CO3-mediated cyclization

A modular 2H-azirine synthesis from ketoxime acetates via Cs2CO3-mediated cyclization has been developed. The reaction utilizes easily available starting materials and provides a general synthetic route to 2,3-diaryl-2H-azirines in good to excellent yields under mild conditions, which is complementary to the conventional approaches for the synthesis of 2H-azirines. A gram-scale reaction was performed to demonstrate the scale-up applicability of this synthetic method. Importantly, 2H-azirines can be efficiently converted to various azaheterocycles.

Gold-Catalyzed Intermolecular Nitrene Transfer from 2H-Azirines to Ynamides: A Direct Approach to Polysubstituted Pyrroles

(Chemical Equation Presented). An effective gold-catalyzed intermolecular nitrene transfer by the reaction of 2H-azirines and ynamides is reported, which provides highly substituted pyrroles in a straightforward manner. This transformation proceeds under mild conditions and gives the polysubstituted pyrroles in good-to-excellent yields. Preliminary results indicate that a nongold carbenoid pathway is preferred for current pyrrole synthesis.

REDUCTIVE CONVERSION OF NITRO ALKENES TO KETONES AND/OR OXIMES IN AN AQUEOUS HClO4-CH2Cl2-DIOXANE-(Pb) SYSTEM

Electrochemical and chemical reduction of nitro alkenes in an aqueous HClO4-CH2Cl2-dioxane-(Pb) system afforded ketones and oximes in good yields, each of which can be obtained selectively by treating with either aqueous formaldehyde or hydroxylamine as a proper workup process, respectively.