1454802-99-3

Basic information

• Product Name: C₁₁H₁₈N₃O₃⁽¹⁺⁾*C₉H₁₁O₃S^(1-)
• Synonyms: C₁₁H₁₈N₃O₃⁽¹⁺⁾*C₉H₁₁O₃S^(1-)
• CAS NO: 1454802-99-3
• Molecular Weight: 439.533
• Mol File: 1454802-99-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₁H₁₈N₃O₃⁽¹⁺⁾*C₉H₁₁O₃S^(1-)(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₁H₁₈N₃O₃⁽¹⁺⁾*C₉H₁₁O₃S^(1-)(1454802-99-3)
• EPA Substance Registry System: C₁₁H₁₈N₃O₃⁽¹⁺⁾*C₉H₁₁O₃S^(1-)(1454802-99-3)

Safety Data

• Hazardous Substances Data: 1454802-99-3(Hazardous Substances Data)

Upstream product

• 38202-27-6 ethyl O-(2-mesitylenesulfonyl)acetohydroxamate 
• 36016-40-7 mesitylenesulfonylhydroxylamine 
• 183741-80-2 tert-butyl N-(6-methoxypyridin-3-yl)carbamate 

Relevant articles and documents

Phosphodiesterase inhibitors. Part 6: Design, synthesis, and structure-activity relationships of PDE4-inhibitory pyrazolo[1,5-a]pyridines with anti-inflammatory activity

We previously identified KCA-1490 [(-)-6-(7-methoxy-2-trifluoromethyl- pyrazolo[1,5-a]pyridin-4-yl)-5-methyl-4,5-dihydro-3-(2H)-pyridazinone], a dual PDE3/4 inhibitor. In the present study, we found highly potent selective PDE4 inhibitors derived from the structure of KCA-1490. Among them, N-(3,5-dichloropyridin-4-yl)-7-methoxy-2-(trifluoromethyl)pyrazolo[1,5-a] pyridine-4-carboxamide (2a) had good anti-inflammatory effects in an animal model.