145508-18-5

Basic information

• Product Name: Butanamide, 2-[bis(methylthio)methylene]-3-oxo-N-phenyl-
• CAS NO: 145508-18-5
• Molecular Formula: C13H15NO2S2
• Molecular Weight: 281.4
• Mol File: 145508-18-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Butanamide, 2-[bis(methylthio)methylene]-3-oxo-N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanamide, 2-[bis(methylthio)methylene]-3-oxo-N-phenyl-(145508-18-5)
• EPA Substance Registry System: Butanamide, 2-[bis(methylthio)methylene]-3-oxo-N-phenyl-(145508-18-5)

Safety Data

• Hazardous Substances Data: 145508-18-5(Hazardous Substances Data)

Upstream product

• 75-15-0 carbon disulfide 
• 102-01-2 N-phenylacetoacetamide 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 1036739-37-3 2-(bis(methylthio)methylene)-3-chloro-N-phenylbut-3-enamide 
• 70254-43-2 4-Hydroxy-2-quinolone 
• 26138-64-7 4-hydroxy-3-acetyl-1H-quinoline-2-one 
• 1386383-04-5 3-acetyl-4-(benzylamino)quinolin-2(1H)-one 
• 1386383-07-8 4-(methylthio)-3-(5-phenyl-4,5-dihydroisoxazol-3-yl)quinolin-2(1H)-one 
• 1612232-15-1 2-(bis(methylthio)methylene)-3-ethoxy-N-phenylbutanamide 
• 1612231-83-0 3-(1-ethoxyethyl)-4-(methylthio)-1-phenylquinolin-2(1H)-one 
• 1232688-92-4 - 
• 313398-24-2 3-acetyl-4-(4-methylphenyl)-1,2-dihydroquinolin-2-one 
• 1338704-24-7 2-amino-5-[2,2-dicyano-1-(methylthio)vinyl]-4-methyl-6-oxo-1-phenyl-1,6-dihydropyridine-3-carbonitrile 
• 1201954-00-8 C₁₂H₁₂N₂O₂S 
• 1201953-85-6 C₁₂H₁₃N₃OS 

Relevant articles and documents

Free radical rearrangement synthesis and microbiological evaluation of novel 2-sulfoether-4-quinolone scaffolds as potential antibacterial agents

To develop novel antibacterial agents, 2-sulfoether-4-quinolone scaffolds were synthesized by a free radical process and evaluated for their antibacterial abilities. Excellent activities against Gram-positive bacteria were observed, among which compounds 3m, 3n, 3p and 3t possessed the lowest MICs against both S. aureus and B. cereus (0.8 μM and 1.61 μM, respectively). The structure-activity relationship (SAR) showed that: (i) the antibacterial activity was related to the substituent, such as 2-SCH3 = 2-SCH2CH3 > 2-S(=O)CH3 > 2-OH, 8-Br > 7-Br > 6-Br; (ii) -CF3 increased the antibacterial activity; (iii) the di-substituted group performed the better activity. The DNA supercoiling inhibitory analysis confirmed their fluoroquinolone characters. The docking showed that compound 3n was nicely bound into the DNA-gryase complex via extensive interactions, including conventional hydrogen bonds, halogen bonds and hydrophobic interactions. The microscopy analysis of compound 3n against S. aureus exhibited the damages on the cell wall construction, which may facilitate the penetration into Gram-positive bacteria.

HETEROARYL INHIBITORS OF PAD4

The present invention provides compounds useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.

Substituted quinolinones. 18. 3-Acetyl-4-methylthioquinolin-2(1H)-one as useful synthon intermediate for synthesis of some new quinolinones

3-Acetyl-4-methylthioquinolin-2(1H)-one (3) has been prepared and its reactivity towards treatment with different reagents, dilute sulfuric acid, aqueous sodium hydroxide, and hydrogen peroxide, is described. The reactions of compound 3 with benzylamine,