1455438-47-7Relevant articles and documents
Asymmetric Synthesis of α-Amino Ketones by Bronsted Acid Catalysis
Wen, Wei,Zeng, Yu,Peng, Li-Yu,Fu, Li-Na,Guo, Qi-Xiang
, p. 3922 - 3925 (2015)
The highly efficient, regioselective, and enantioselective transfer hydrogenation of α-keto ketimines and reductive amination of diketones by Bronsted acid catalysis is described. A series of chiral α-amino ketones is prepared in high yields (up to >99%), excellent regioselectivities (up to >99:1), and enantioselectivities (up to 98% ee). This method has broad substrate scope.