145654-01-9Relevant articles and documents
Synthesis and neuroprotective effects of novel chalcone-triazole hybrids
Sooknual, Pichjira,Pingaew, Ratchanok,Phopin, Kamonrat,Ruankham, Waralee,Prachayasittikul, Supaluk,Ruchirawat, Somsak,Prachayasittikul, Virapong
, (2020)
The development of novel neuroprotective agents is urgently needed for the treatment of neurodegenerative diseases, affecting aging individuals worldwide. In this study, a new set of chalcone-triazole hybrids (6a-g) was synthesized and evaluated for their
Anti-leishmanial click modifiable thiosemicarbazones: Design, synthesis, biological evaluation and in silico studies
Temraz, Mohamed G.,Elzahhar, Perihan A.,El-Din A. Bekhit, Alaa,Bekhit, Adnan A.,Labib, Hala F.,Belal, Ahmed S.F.
, p. 585 - 600 (2018)
Leishmaniasis is a devastating tropical disease with limited therapeutic options. Depending on recently reported active anti-leishmanial compounds, we designed and synthesized a series of click modifiable 1,2,3-triazole and thiosemicarbazone hybrids. Most
A strategic approach to the synthesis of ferrocene appended chalcone linked triazole allied organosilatranes: Antibacterial, antifungal, antiparasitic and antioxidant studies
Singh, Gurjaspreet,Arora, Aanchal,Kalra, Pooja,Maurya, Indresh Kumar,Ruizc, Cristobal Espinosa,Estebanc, M. Angeles,Sinha, Shweta,Goyal, Kapil,Sehgal, Rakesh
, p. 188 - 195 (2019)
A series of ferrocene appended chalcone allied triazole coupled organosilatranes (FCTSa 7–FCTSa 12) were synthesised with the aim of amalgamating the pharmacological action of the constituting moieties into a single molecular scaffold. All the synthesised
APOPTOSIS INHIBITORS
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Paragraph 0376, (2018/02/27)
The invention provides compounds that are inhibitors or covalent modifiers of succinate dehydrogenase subunit B (SDHB) and/or inhibitors of apoptosis, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition.