1456621-40-1

Basic information

• Product Name: N¹-(6,7-bis(2-methoxyethoxy)quinazolin-4-yl)-N²,N²-bis(2-chloroethyl)benzene-1,2-diamine hydrochloride
• Synonyms: N¹-(6,7-bis(2-methoxyethoxy)quinazolin-4-yl)-N²,N²-bis(2-chloroethyl)benzene-1,2-diamine hydrochloride
• CAS NO: 1456621-40-1
• Molecular Weight: 545.894
• Mol File: 1456621-40-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N¹-(6,7-bis(2-methoxyethoxy)quinazolin-4-yl)-N²,N²-bis(2-chloroethyl)benzene-1,2-diamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: N¹-(6,7-bis(2-methoxyethoxy)quinazolin-4-yl)-N²,N²-bis(2-chloroethyl)benzene-1,2-diamine hydrochloride(1456621-40-1)
• EPA Substance Registry System: N¹-(6,7-bis(2-methoxyethoxy)quinazolin-4-yl)-N²,N²-bis(2-chloroethyl)benzene-1,2-diamine hydrochloride(1456621-40-1)

Safety Data

• Hazardous Substances Data: 1456621-40-1(Hazardous Substances Data)

Upstream product

• 100858-18-2 N,N-bis(2-chloroethyl)-2-nitroaniline 
• 179688-29-0 6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one 
• 179688-27-8 ethyl 2-amino-4,5-bis(2-methoxyethoxy)-benzoate 
• 179688-26-7 2-nitro-4,5-bis(2-methoxyethoxy)benzoic acid ethyl ester 
• 183322-16-9 3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester 
• 3943-89-3 Ethyl protocatechuate 
• 13686-21-0 N¹,N¹-bis(2-chloroethyl)benzene-1,2-diamine 
• 183322-18-1 4-chloro-6,7-bis(2-methoxyethoxy)quinazoline 

Relevant articles and documents

Design and synthesis of novel quinazoline nitrogen mustard derivatives as potential therapeutic agents for cancer

Thirteen novel quinazoline nitrogen mustard derivatives were designed, synthesized and evaluated for their anticancer activities in vitro and in vivo. Cytotoxicity assays were carried out in five cancer cell lines (HepG2, SH-SY5Y, DU145, MCF-7 and A549) and one normal human cell line (GES-1), in which compound 22b showed very low IC50 to HepG2 (the IC50 value is 3.06 μM), which was lower than Sorafenib. Compound 22b could inhibit cell cycle at S and G2/M phase and induce cell apoptosis. In the HepG2 xenograft model, 22b exhibited significant cancer growth inhibition with low host toxicity in vivo.