1457884-79-5Relevant articles and documents
Trisubstitution of pyridine through sequential and regioselective palladium cross-coupling reactions affording analogs of known GPR54 antagonists
Doebelin, Christelle,Wagner, Patrick,Bertin, Isabelle,Simonin, Frederic,Schmitt, Martine,Bihel, Frederic,Bourguignon, Jean-Jacques
, p. 10296 - 10300 (2013/09/02)
Because of their large spectrum of applications, poly-functionalized pyridines remain an attractive challenge in modern organic chemistry. We describe the poly-functionalization of halopyridines through a series of sequential and regioselective palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Sonogashira and Buchwald-Hartwig reactions). This strategy was applied to the synthesis of several analogs of single non-peptidic known GPR54 antagonists. The Royal Society of Chemistry 2013.