145790-51-8 Usage
Description
(S)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(TERT-BUTYLDIPHENYLSILYLOXY)PROPANOIC ACID, also known as Boc-Asp(OtBu)-OH, is a chemical compound that serves as a crucial building block in peptide synthesis. It is a derivative of aspartic acid, featuring a tert-butoxycarbonyl (Boc) protecting group that shields the amino group during synthesis, and a diphenylsilyloxy group that protects the hydroxyl group. (S)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(TERT-BUTYLDIPHENYLSILYLOXY)PROPANOIC ACID plays a significant role in medicinal chemistry and drug development, enabling the creation of novel peptide-based drugs and facilitating the study of structure-activity relationships of peptide molecules in biological systems.
Uses
Used in Pharmaceutical Industry:
(S)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(TERT-BUTYLDIPHENYLSILYLOXY)PROPANOIC ACID is used as a key intermediate in the synthesis of peptide-based drugs for various therapeutic applications. Its role in protecting the functional groups of aspartic acid allows for the controlled assembly of complex peptide structures, enhancing the development of innovative medications.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (S)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(TERT-BUTYLDIPHENYLSILYLOXY)PROPANOIC ACID is utilized as a valuable tool for studying the structure-activity relationships of peptide molecules. This understanding is essential for optimizing the pharmacological properties of peptide drugs, such as potency, selectivity, and stability.
Used in Drug Development:
(S)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(TERT-BUTYLDIPHENYLSILYLOXY)PROPANOIC ACID is employed in the development of new drugs, particularly in the design and synthesis of peptide therapeutics. Its protective groups enable the synthesis of peptides with specific functionalities and biological activities, contributing to the advancement of targeted and effective treatments for various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 145790-51-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,7,9 and 0 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 145790-51:
(8*1)+(7*4)+(6*5)+(5*7)+(4*9)+(3*0)+(2*5)+(1*1)=148
148 % 10 = 8
So 145790-51-8 is a valid CAS Registry Number.
145790-51-8Relevant articles and documents
Tataricins A and B, two novel cyclotetrapeptides from Aster tataricus, and their absolute configuration assignment
Xu, Hui-Min,Yi, Hua,Zhou, Wen-Bing,He, Wen-Jun,Zeng, Gang-Zhi,Xu, Wen-Yan,Tan, Ning-Hua
, p. 1380 - 1383 (2013/04/23)
Two novel cyclotetrapeptides, tataricins A and B, with a unique cyclopeptide backbone and aδ 2,4Pro side chain, were isolated from the traditional Chinese medicine Aster tataricus. Their structures and absolute configurations were determined using a combination of spectroscopic data, the advanced Marfey's method, and a total synthesis. Copyright
Novel orally active morpholine N-arylsulfonamides γ-secretase inhibitors with low CYP 3A4 liability
Josien, Hubert,Bara, Thomas,Rajagopalan, Murali,Clader, John W.,Greenlee, William J.,Favreau, Leonard,Hyde, Lynn A.,Nomeir, Amin A.,Parker, Eric M.,Song, Lixin,Zhang, Lili,Zhang, Qi
scheme or table, p. 6032 - 6037 (2010/05/18)
A new class of 2,6-disubstituted morpholine N-arylsulfonamide γ-secretase inhibitors was designed based on the introduction of a morpholine core in lieu or piperidine in our lead series. This resulted in compounds with improved CYP 3A4 profiles. Several a
SUBSTITUTED N-ARYLSULFONYLHETEROCYCLIC AMINES AS GAMMA-SECRETASE INHIBITORS
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Page/Page column 66, (2010/02/15)
This invention discloses novel gamma secretase inhibitors of the formula I: wherein: L is -O- , -N(R6)-, -S-, -S(O)-, or -S(O2)-; R1 is selected from the group consisting of aryl and heteroaryl; R2 is selected f
