Welcome to LookChem.com Sign In|Join Free

CAS

  • or

1458715-57-5

Post Buying Request

1458715-57-5 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

1458715-57-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1458715-57-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,5,8,7,1 and 5 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1458715-57:
(9*1)+(8*4)+(7*5)+(6*8)+(5*7)+(4*1)+(3*5)+(2*5)+(1*7)=195
195 % 10 = 5
So 1458715-57-5 is a valid CAS Registry Number.

1458715-57-5Downstream Products

1458715-57-5Relevant articles and documents

Synthesis and study of benzothiazole conjugates in the control of cell proliferation by modulating Ras/MEK/ERK-dependent pathway in MCF-7 cells

Kamal, Ahmed,Faazil, Shaikh,Ramaiah, M. Janaki,Ashraf, Md.,Balakrishna,Pushpavalli,Patel, Nibedita,Pal-Bhadra, Manika

, p. 5733 - 5739 (2013/10/01)

By applying a methodology, a series of benzothiazole-pyrrole based conjugates (4a-r) were synthesized and evaluated for their antiproliferative activity. Compounds such as 4a, 4c, 4e, 4g-j, 4m, 4n, 4o and 4r exhibited significant cytotoxic effect in the MCF-7 cell line. Cell cycle effects were examined for these conjugates at 2 μM as well as 4 μM concentrations and FACS analysis show an increase of G2/M phase cells with concomitant decrease of G1 phase cells thereby indicating G2/M cell cycle arrest by them. Interestingly 4o and 4r are effective in causing apoptosis in MCF-7 cells. Moreover, 4o showed down regulation of oncogenic expression of Ras and its downstream effector molecules such as MEK1, ERK1/2, p38 MAPK and VEGF. The apoptotic aspect of this conjugate is further evidenced by increased expression of caspase-9 in MCF-7 cells. Hence these small molecules have the potential to control both the cell proliferation as well as the invasion process in the highly malignant breast cancers.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1458715-57-5