1459-96-7

Basic information

• Product Name: dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate
• Synonyms: dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate;DiMethyl -bicyclo[2.2.2]octan-1,4-dicarboxylate;Bicyclo[2.2.2]octane-1,4-dicarboxylic acid dimethyl ester;2,2-diMethylbicyclo[2.2.2]octane-1,4-dicarboxylate;Bicyclo[2.2.2]octane-1,4-dicarboxylic acid, 1,4-diMethyl ester;iMethyl bicyclo[2.2.2]octane-1,4-dicarboxylate;1,4-dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate;Dimethyl bioyclo[2.2.2]octane-1,4-dicarboxylate
• CAS NO: 1459-96-7
• Molecular Formula: C₁₂H₁₈O₄
• Molecular Weight: 226.27
• Mol File: 1459-96-7.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 273.6 °C at 760 mmHg
• Flash Point: 126.968 °C
• Appearance: white crystal
• Density: 1.206 g/cm³
• Vapor Pressure: 0.00568mmHg at 25°C
• Refractive Index: 1.515
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate(1459-96-7)
• EPA Substance Registry System: dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate(1459-96-7)

Safety Data

• Hazardous Substances Data: 1459-96-7(Hazardous Substances Data)

Usage

Uses

Dimethyl Bicyclo[2.2.2]octane-1,4-dicarboxylate is used in preparation of cycloalkanecarboxamides and related compounds as modulators of the integrated stress pathway.

InChI:InChI=1/C12H18O4/c1-15-9(13)11-3-6-12(7-4-11,8-5-11)10(14)16-2/h3-8H2,1-2H3

Upstream product

• 1659-67-2 dimethyl bicyclo[2.2.2]oct-2-ene-1,4-dicarboxylate 
• 94-60-0 dimethyl 1,4-cyclohexane dicarboxylate 
• 107-04-0 1-Bromo-2-chloroethane 
• 62476-38-4 (1R,3R,6R,8R)-Tricyclo[4.2.0.0^3,8]octane-3,6-dicarboxylic acid dimethyl ester 
• 29412-62-2 dimethyl pentacyclo[4.2.0.0.^2,50.^3,80^4,7]octane-1,4-dicarboxylate 
• 619-81-8 cyclohexane-1,4-dicarboxylic acid 
• 340023-18-9 cis/trans-1-(2-iodoethyl)-cyclohexane-1,4-dicarboxylic acid dimethyl ester 
• 100-21-0 terephthalic acid 
• 1659-95-6 dimethyl 1,3-cyclohexadiene-1,4-dicarboxylate 
• 6289-46-9 dimethyl 2,5-dioxocyclohexane-1,4-dicarboxylate 
• 57293-62-6 dimethyl 1,4-dioxobicyclo<2.2.2>octane-2,5-dicarboxylate 
• 106004-06-2 dimethyl 1-(2'-chloroethyl)cyclohexane-1,4-dicarboxylate 
• 54774-94-6 4-acetoxybicyclo<2.2.2>octan-1-ol 
• 10364-35-9 1,4-Diacetoxybicyclo<2.2.2>octane 

Downstream Products

• 711-02-4 1,4-bicyclo[2.2.2]octanedicarboxylic acid 
• 18720-35-9 bicyclo[2.2.2]octane-1,4-dicarboxylic acid monomethyl ester 
• 105176-66-7 (4-aminobicyclo[2.2.2]octan-1-yl)methanol 
• 1333384-43-2 tert-butyl (4-(hydroxymethyl)bicyclo[2.2.2]octane-1-yl)carbamate 
• 826-45-9 Bicyclo<2.2.2>octane-1,4-dimethanol 
• 94994-15-7 4-hydroxymethyl-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester 
• 78385-84-9 4-fluorobicyclo<2.2.2>octane-1-carboxylic acid 
• 1246852-77-6 2-amino-1-(4-(4-bromophenyl)bicyclo[2.2.2]octan-1-yl)ethanone hydrochloride 
• 1246852-76-5 1-(4-(4-bromophenyl)bicyclo[2.2.2]octan1-yl)-2-chloroethanone 
• 1246852-75-4 methyl 4-(4-bromophenyl)bicyclo[2.2.2]octane-1-carboxylate 

Relevant articles and documents

Rodlike molecules by Kolbe electrolysis

A new short and simple pathway to rigid, rod-shaped hydrocarbon skeletons, in particular of the oligo-bicyclo[2.2.2]octane type, is described. The key step consists of an electrochemical C-C bond coupling reaction between bridgehead positions of bi- and tricyclic carboxylic acids. Functional groups can be retained, they influence the yield of the C-C bond connection. In this way, otherwise difficult or laborious syntheses are shortened, and rigid, non-collapsable nano size spacer units are easily available. The optimized electrochemical procedures are described in detail.

Unique gas and hydrocarbon adsorption in a highly porous metal-organic framework made of extended aliphatic ligands

High and unique gas and hydrocarbon adsorption in a highly stable guest-free microporous metal-organic framework constructed on rigid aliphatic ligands, H2bodc and ted, is reported in this work. The Royal Society of Chemistry.

Bicyclo [2.2.2] octane - 1, 4 - dicarboxylic acid mono methyl ester synthesis method

The invention relates to a synthetic method of an organic compound. The synthetic method of bicyclo-[2.2.2]octane-1,4-dicarboxylic acid monomethyl easter is as follows: firstly, adopting sodium hydride, DMSS and 1,2-dibromoethane to synthesize the intermediate I; secondly, adopting the intermediate I, sodium acetate, ammourea hydrochloride and alcohol to synthesize semicarbazon; thirdly, adopting potassium hydroxide, diethylene glycol and semicarbazon to synthesize target diacid; fourthly, adopting target diacid, thionyl chloride and methanol to synthesize target diester; and fifthly, adopting target diester, potassium hydroxide and 95% of methanol water solution to synthesize the target product monoester. The invention has reasonable synthetic process route, mild process conditions, environment friendly, easy operation, low raw material cost, high product yield and excellent purity, and is applicable to industrial production and satisfies the application requirement of each industry.

SPIRO AZETIDINE ISOXAZOLE DERIVATIVES AND THEIR USE AS SSTR5 ANTAGONISTS

Provided is a compound represented by the following formula (1) or a salt thereof, which has an SSTR5 antagonistic action: wherein each symbol has the same definition as in the specification.