145943-75-5

Basic information

• Product Name: 1-Piperazinepropanol,4-acetyl-(9CI)
• Synonyms: 1-Piperazinepropanol,4-acetyl-(9CI);3-(4-ACETYLPIPERAZIN-1-YL)PROPAN-1-OL
• CAS NO: 145943-75-5
• Molecular Formula: C₉H₁₈N₂O₂
• Molecular Weight: 186.25
• Product Categories: PIPERIDINE
• Mol File: 145943-75-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Piperazinepropanol,4-acetyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperazinepropanol,4-acetyl-(9CI)(145943-75-5)
• EPA Substance Registry System: 1-Piperazinepropanol,4-acetyl-(9CI)(145943-75-5)

Safety Data

• Hazardous Substances Data: 145943-75-5(Hazardous Substances Data)

Usage

Derivative of

Piperazine and propanol

Pharmacological properties

Serotonin receptor agonist

Potential use

Ingredient in pharmaceutical formulations

Industry interest

Pharmaceutical and chemical industries

Upstream product

• 69414-53-5 1-(piperazin-1-yl)ethanone hydrochloride 
• 627-30-5 1-chloro-3-hydroxypropane 
• 13889-98-0 N-acetylpiperidine 
• 627-18-9 1-bromo-3-propanol 

Downstream Products

• 1240299-34-6 6-(4-{4-[2-(4-acetylpiperazin-1-yl)ethoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine napadisylate 
• 1240299-37-9 6-(4-{4-[2-(4-acetylpiperazin-1-yl)ethoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine fumarate 
• 1240299-36-8 6-(4-{4-[2-(4-acetylpiperazin-1-yl)ethoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine maleate 
• 1240299-31-3 6-[4-[4-[3-(4-acetylpiperazin-1-yl)propoxy]phenyl]piperidin-1-yl]-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine 
• 1166819-39-1 6-[4-[4-[3-(4-acetylpiperazin-1-yl)propoxy]phenyl]piperidin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine 
• 1240299-33-5 1-(4-(2-(4-(1-(3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl)phenoxy)ethyl)piperazin-1-yl)ethanone 
• 1240300-00-8 4-[4-[3-(4-acetylpiperazin-1-yl)propoxy]phenyl]piperidine 
• 1240299-99-3 benzyl 4-[4-[3-(4-acetylpiperazin-1-yl)propoxy]phenyl]-5,6-dihydropyridine-1(2H)-carboxylate 
• 393785-31-4 3-(-4-acetylpiperazino)propyl 4-nitrophenylcarbonate 

Relevant articles and documents

KRAS G12C INHIBITORS

The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

NEW ACETYL COENZYME A CARBOXYLASE (ACC) INHIBITORS AND USES IN TREATMENTS OF OBESITY AND DIABETES MELLITUS - 087

The present invention relates to Acetyl Coenzyme A Carboxylase (ACC) inhibitors according to formula (I), or an enantiomer thereof, or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, E, L, Z and n are as defined herein, to processes for preparing such compounds, to pharmaceutical compositions containing them, to the use of such inhibitors and to methods for th eir therapeutic use, particularly in the treatments of obesity and diabetes mellitus.

8-CHLORO AND 8-METHYLTHIO DERIVATIVES OF 10-PIPERAZINO-10,11-DIHYDRODIBENZOTHIEPINS; NEW COMPOUNDS AND NEW PROCEDURES

The resolution of racemic clorothepin (Ia) was repeated and the water-soluble methanesulfonates of (S)(+)-clorothepin and (R)(-)-clorothepin were prepared which were used in recent studies of the stereoselectivity of action of this neuroleptic agent.Alkylation of the secondary amine VIa with 2-chloroethyl decanoate resulted in noroxyclothepin decanoate IVa whose basically catalyzed ethanolysis afforded smoothly the amino alcohol IIa.Reactions of amines VIa and VIb with 1,2-butene oxide gave the amino alcohols VIIab.Alkylation of the amine VIa with 5-bromopentan-2-oneand the following reduction of the amino ketone IXa formed gave the amino alcohol VIIIa.Amino alcohols IIa and IIIb were transformed by treatment with thionyl chloride to the chloroalkylamines Xa and XIb which were used for the synthesis of mandelates XIIa, XIIIb and benzilates XIVa, XVb derived from noroxyclothepin IIa and oxyprothepin IIIb.A substitution reaction of 2,11-dichloro-10,11-dihydrodibenzothiepin with 1,4-diazabicyclononane led to the clorothepin analogue XVI.From 2-chlorodibenzothiepin-10(11 H)-one XVII via the 11-bromo derivative XVIII the amino ketone XIX was prepared.While its reduction with sodium borohydride gave the cis-amino alcohol XXI, the reduction with diborane gave the trans-amino alcohol XXII.The pharmacological properties of the new piperazine derivatives are described; some of them showed a high degree of neuroleptic activity of various profile.