146256-98-6

Basic information

• Product Name: Ethyl N-Boc-4-Oxopyrrolidine-3-carboxylate
• Synonyms: Ethyl N-Boc-4-Oxopyrrolidine-3-carboxylate;Ethyl 1-tert-butyloxycarbonyl-4-oxopyrrolidine-3-carboxylate;Ethyl 1-Boc-4-Oxopyrrolid...;1,3-Pyrrolidinedicarboxylic acid 4-oxo-1-(1,1-dimethylethyl) 3-ethyl ester;Ethyl 1-Boc-4-Oxopyrrolidine-3-carboxylate;1-Boc-4-oxo-pyrrolidine-3-carboxylic acid ethyl ester;1-(tert-Butoxycarbonyl)pyrrolidin-3-one-4-carboxylic acid ethyl ester;Ethyl 1-tert-butoxycarbonyl-3-oxopyrrolidine-4-carboxylate
• CAS NO: 146256-98-6
• Molecular Formula: C₁₂H₁₉NO₅
• Molecular Weight: 257.28
• Product Categories: Amino Acids and Derivatives;Carbonyl Compounds;CHIRAL CHEMICALS
• Mol File: 146256-98-6.mol
• Article Data: 11

Chemical Properties

• Melting Point: 54.0 to 59.0 °C
• Boiling Point: 120°C/0.4mmHg(lit.)
• Flash Point: 164.3 °C
• Appearance: /
• Density: 1.182
• Vapor Pressure: 5.17E-05mmHg at 25°C
• Refractive Index: 1.486
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 11.19±0.20(Predicted)
• CAS DataBase Reference: Ethyl N-Boc-4-Oxopyrrolidine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl N-Boc-4-Oxopyrrolidine-3-carboxylate(146256-98-6)
• EPA Substance Registry System: Ethyl N-Boc-4-Oxopyrrolidine-3-carboxylate(146256-98-6)

Safety Data

• Statements: 36/38
• Safety Statements: 36
• HazardClass: IRRITANT
• Hazardous Substances Data: 146256-98-6(Hazardous Substances Data)

Usage

Description

Ethyl N-Boc-4-Oxopyrrolidine-3-carboxylate, also known as 1-tert-butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate, is a white to slightly yellow crystalline powder. It is a valuable research chemical with unique chemical properties that make it suitable for various applications in different industries.

Uses

Used in Pharmaceutical Industry:
Ethyl N-Boc-4-Oxopyrrolidine-3-carboxylate is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows for the development of new drugs with potential therapeutic applications.
Used in Chemical Research:
As a research chemical, Ethyl N-Boc-4-Oxopyrrolidine-3-carboxylate is used in the development and testing of new chemical reactions and processes. Its properties make it a valuable tool for understanding the behavior of similar compounds and for advancing the field of organic chemistry.
Used in Material Science:
Ethyl N-Boc-4-Oxopyrrolidine-3-carboxylate may also find applications in the field of material science, where its unique properties can be utilized to develop new materials with specific characteristics, such as improved stability or reactivity.

InChI:InChI=1/C12H19NO5/c1-5-17-10(15)8-6-13(7-9(8)14)11(16)18-12(2,3)4/h8H,5-7H2,1-4H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 541-41-3 chloroformic acid ethyl ester 
• 101385-93-7 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 3783-61-7 diethyl 2-azabutane-1,4-dicarboxylate 
• 140-88-5 ethyl acrylate 
• 31954-27-5 N-(tert-butoxycarbonyl)glycine methyl ester 
• 14719-37-0 ethyl 2-(tert-butoxycarbonylamino)acetate 
• 146256-97-5 3-(tert-butoxycarbonyl-ethoxycarbonylmethyl-amino)-propionic acid ethyl ester 

Downstream Products

• 101385-93-7 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1280210-79-8 2,6-dihydropyrrole [3,4-c]pyrazole-5(4H)-carboxylic acid tert-butyl ester 
• 895243-98-8 (3R,4S)-4-Amino-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester 
• 267230-40-0 (3S,4R)-1-(N-tert-butoxycarbonyl)-3-[(1'R)-phenylethylamino]-4-ethoxycarbonylpyrrolidine 
• 1186654-76-1 (+/-)-trans-tert-butyl 3-(hydroxymethyl)-4-(4-methoxyphenyl)-pyrrolidine-1-carboxylate 

Relevant articles and documents

(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements and Structural and Biological Investigation

Starting from 1-4 and 7 structural templates, analogues based on bioisosteric replacements (5a-c vs 1, 2 and 6 vs 7) were synthesized for completing the SAR analysis. Interesting binding properties at GluA2, GluK1, and GluK3 receptors were discovered. The requirements for GluK3 interaction were elucidated by determining the X-ray structures of the GluK3-LBD with 2 and 5c and by computational studies. Antinociceptive potential was demonstrated for GluK1 partial agonist 3 and antagonist 7 (2 mg/kg ip).

Preparation method for omarigliptin midbody

The invention provides an efficient and simple preparation method for omarigliptin midbody pyrrole and [3,4-c] pyrazol-5(2H,4H,6H)-carboxylic acid tert-butyl ester, wherein the total recovery ratio is close to 50%. The preparation method is easy to operate, the recovery ratio is higher, three produced wastes are less, and the method is suitable for industrialized production.

ANTI-ANGIOGENESIS COMPOUND, INTERMEDIATE AND USE THEREOF

Disclosed are an anti-abnormal proliferation of angiogenesis compound represented by formula I, use and intermediate thereof. The compound has good effect against abnormal proliferation of angiogenesis, and the activity of the compound is produced by inhibiting VEGFR2. The compound can be used for treating diseases, such as wet macular degeneration, inflammation, malignant tumor and the like, caused by abnormity of angiogenesis and protein kinases such as VEGFR2, FGFR2 and the like.