146304-02-1

Basic information

• Product Name: (S)-1-(3-chloro-1-phenylpropoxy)-3-iodobenzene
• Synonyms: (S)-1-(3-chloro-1-phenylpropoxy)-3-iodobenzene
• CAS NO: 146304-02-1
• Molecular Weight: 372.633
• Mol File: 146304-02-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-1-(3-chloro-1-phenylpropoxy)-3-iodobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(3-chloro-1-phenylpropoxy)-3-iodobenzene(146304-02-1)
• EPA Substance Registry System: (S)-1-(3-chloro-1-phenylpropoxy)-3-iodobenzene(146304-02-1)

Safety Data

• Hazardous Substances Data: 146304-02-1(Hazardous Substances Data)

Upstream product

• 626-02-8 3-Iodophenol 
• 100306-34-1 3-chloro-1-phenylpropanol 
• 100306-33-0 (1R)-3-chloro-1-phenylpropanol 

Relevant articles and documents

Bicyclic Diazepinones as Dual Ligands of the α2δ-1 Subunit of Voltage-Gated Calcium Channels and the Norepinephrine Transporter

The synthesis and pharmacological activity of a new series of bicyclic diazepinones with dual activity toward the α2δ-1 subunit of voltage-gated calcium channels (Cavα2δ-1) and the norepinephrine transporter (NET) are reported. Exploration of the positions amenable for substitution on a nonaminoacidic Cavα2δ-1 scaffold allowed the identification of favorable positions for the attachment of NET pharmacophores. Among the patterns explored, attachment of the 2-ethylamino-9-methyl-6-phenyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-e][1,4]diazepin-5-one framework to the meta-position of the phenyl ring of the 3-methylamino-1-phenylpropoxy and 3-methylamino-1-thiophenylpropoxy moieties provided dual compounds with excellent NET functionality. Alternative bicyclic frameworks were also explored, and some lead molecules were identified, which showed a balanced dual profile and exhibited good ADMET properties.