146334-96-5

Basic information

• Product Name: 3-phenyl-5-carbomethoxy-5-(diphenylmethyleneamino)-4,5-dihydroisoxazole
• Synonyms: 3-phenyl-5-carbomethoxy-5-(diphenylmethyleneamino)-4,5-dihydroisoxazole
• CAS NO: 146334-96-5
• Molecular Weight: 384.434
• Mol File: 146334-96-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-phenyl-5-carbomethoxy-5-(diphenylmethyleneamino)-4,5-dihydroisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenyl-5-carbomethoxy-5-(diphenylmethyleneamino)-4,5-dihydroisoxazole(146334-96-5)
• EPA Substance Registry System: 3-phenyl-5-carbomethoxy-5-(diphenylmethyleneamino)-4,5-dihydroisoxazole(146334-96-5)

Safety Data

• Hazardous Substances Data: 146334-96-5(Hazardous Substances Data)

Upstream product

• 934-16-7 phenylhydroxamoyl chloride 
• 873-67-6 benzonitrile oxide 
• 118553-21-2 Methyl N-(diphenylmethylene)-α,β-didehydroalaninate 

Relevant articles and documents

4,5-Dihydroisoxazole and 4,5-Dihydro-1,2,4-oxadiazole Derivatives from Cycloaddition Reactions of Nitrile Oxides to Alkyl N-(Diphenylmethylene)α,β-dehydroamino Acids

The alkyl N-(diphenylmethylene)-α,β-dehydroamino acids 1 have been submitted to 1,3-dipolar cycloadditions with nitrile oxides.The reactivity of these compounds depends on the type and on the stereochemistry of the β-substituents.With the unsubstituted terms 1a,b the reaction occurs on the C,C double bond, providing a good method for the synthesis of the 4,5-dihydroisoxazole derivatives 3a,b,c and for the gem-functionalized 4,5-dihydroisoxazoles amino carboxylic ester 5.The β-substituted compounds 1c,d,e, inert to 1,1-dimethylethylnitrile oxide, undergo the reaction to the N,C double bond, thus giving with 2a,b the 4,5-dihydro-1,2,4-oxadiazole derivatives 4.All the reactions occur with high site- and regioselectivity.