146366-01-0

Basic information

• Product Name: 2H-Benzimidazol-2-one,5-fluoro-1,3-dihydro-1-(1-methylethyl)-(9CI)
• Synonyms: 2H-Benzimidazol-2-one,5-fluoro-1,3-dihydro-1-(1-methylethyl)-(9CI);5-fluoro-1-isopropyl-1,3-dihydro-2H-benzo[d]imidazol-2-one
• CAS NO: 146366-01-0
• Molecular Formula: C₁₀H₁₁FN₂O
• Molecular Weight: 194.2055432
• Product Categories: BENZIMIDAZOLE
• Mol File: 146366-01-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2H-Benzimidazol-2-one,5-fluoro-1,3-dihydro-1-(1-methylethyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Benzimidazol-2-one,5-fluoro-1,3-dihydro-1-(1-methylethyl)-(9CI)(146366-01-0)
• EPA Substance Registry System: 2H-Benzimidazol-2-one,5-fluoro-1,3-dihydro-1-(1-methylethyl)-(9CI)(146366-01-0)

Safety Data

• Hazardous Substances Data: 146366-01-0(Hazardous Substances Data)

Usage

General Description

2H-Benzimidazol-2-one, 5-fluoro-1,3-dihydro-1-(1-methylethyl) (9CI) is a chemical compound that belongs to the class of benzimidazoles. It is a heterocyclic compound containing a benzimidazole ring with a fluorine atom and an isopropyl group attached. 2H-Benzimidazol-2-one,5-fluoro-1,3-dihydro-1-(1-methylethyl)-(9CI) has potential pharmaceutical applications due to its structural features that make it suitable for use as a drug or as a precursor in drug synthesis. It may exhibit biological activities such as anti-inflammatory, antiviral, or anticancer properties. Its potential pharmacological properties make it a compound of interest for further research and development in the pharmaceutical industry.

Upstream product

• 530-62-1 1,1'-carbonyldiimidazole 
• 153877-87-3 4-fluoro-N¹-isopropyl-benzene-1,2-diamine 
• 364-78-3 2-nitro-4-fluoroaniline 
• 146366-00-9 4-Fluoro-N-(1-methylethyl)-2-nitrobenzenamine 

Downstream Products

• 240143-39-9 1,3-dihydro-5-fluoro-1-(1-methylethyl)-6-nitro-2H-benzimidazol-2-one 
• 1057215-55-0 C₁₈H₁₉FN₂O₃ 
• 1400655-35-7 4-nitrophenyl 6-fluoro-3-isopropyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-carboxylate 
• 240143-21-9 6-fluoro-3-isopropyl-5-nitro-2-oxo-2,3-dihydro-benzoimidazole-1-carboxylic acid [2-(4-methyl-piperazin-1-yl)-ethyl]-amide 
• 240143-58-2 6-fluoro-3-isopropyl-5-nitro-2-oxo-2,3-dihydro-benzoimidazole-1-carboxylic acid (2-chloro-ethyl)-amide 

Relevant articles and documents

1- Or 3-(3-amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2- ones: Potent, selective, and orally efficacious norepinephrine reuptake inhibitors

Sequential structural modifications of the aryloxypropanamine template (e.g., atomoxetine, 2) led to a novel series of 1-(3-amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors (NRIs). In general, this series of compounds potently blocked the human norepinephrine transporter (hNET) while exhibiting selectivity at hNET against both the human serotonin (hSERT) and dopamine transporters (hDAT). Numerous compounds (e.g., 19-22) had low nonamolar hNET potency with IC 50 values of 7-10 nM and excellent selectivity (>500 fold) at hNET over hSERT and hDAT. Several compounds, such as 20 and 22, were tested in a telemetric rat model of ovariectomized-induced thermoregulatory dysfunction and were efficacious at oral doses of 3 mg/kg in reducing the tail skin temperature. In addition, compound 20 was also studied in the rat hot plate and spinal nerve ligation (SNL) models of acute and neuropathic pain, respectively, and was orally efficacious at doses of 3-10 mg/kg.

Piperidine derivatives, their preparation and their therapeutic application

A compound which is a piperidine derivative of general formula (I) STR1 in which R 1 represents a hydrogen atom, a linear or branched (C 1-6)alkyl group or a cyclo(C 3-8)alkyl group, X represents an oxygen atom, a sulphur atom or a group of general formul