14663-51-5

Basic information

• Product Name: 3-cyclohexylquinazolin-4(3H)-one
• Synonyms: 3-cyclohexylquinazolin-4(3H)-one
• CAS NO: 14663-51-5
• Molecular Weight: 228.294
• Mol File: 14663-51-5.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 3-cyclohexylquinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-cyclohexylquinazolin-4(3H)-one(14663-51-5)
• EPA Substance Registry System: 3-cyclohexylquinazolin-4(3H)-one(14663-51-5)

Safety Data

• Hazardous Substances Data: 14663-51-5(Hazardous Substances Data)

Upstream product

• 118-48-9 isatoic anhydride 
• 108-91-8 cyclohexylamine 
• 122-51-0 orthoformic acid triethyl ester 
• 91-56-5 indole-2,3-dione 
• 4252-31-7 N-formylbenzamide 
• 56814-11-0 anthranilic acid cyclohexylamine 
• 83-34-1 3-Methylindole 
• 117576-29-1 (2?aminophenyl)(1H?benzo[d][1,2,3]triazol?1?yl)methanone 
• 67-68-5 dimethyl sulfoxide 
• 75-91-2 tert.-butylhydroperoxide 
• 348612-65-7 N-cyclohexyl-2-(methylamino)benzamide 
• 68235-96-1 rac-3-chloroindolin-2-one 
• 931-53-3 Cyclohexyl isocyanide 
• 90609-82-8 S-ethyl 2-aminobenzothioate 

Downstream Products

• 127662-34-4 3-Cyclohexyl-1,2,3,4-tetrahydro-quinazoline 
• 1564231-14-6 3-(3-cyclohexyl-4-oxo-1,2,3,4-tetrahydroquinazolin-2-yl)propanenitrile 

Relevant articles and documents

N,N-Dimethylformamide as Carbon Synthons for the Synthesis ofN-Heterocycles: Pyrrolo/Indolo[1,2-a]quinoxalines and Quinazolin-4-ones

N,N-dimethylformamide (DMF) as synthetic precursors contributing especially the methyl, acyl, and amino groups has played a significant role in heterocycle syntheses and functionalization. In this protocol, a wide range of pyrrolo/indolo[1,2-a]quinoxalines and quinazolin-4-ones were obtained in moderate to good yields by using elemental iodine without any metal or peroxides. We considered thatN-methyl andN-acyl of DMF participate and complete the reaction separately through different mechanisms, which displayed potential still to be explored of DMF.

Selective Oxidative Cleavage of 3-Methylindoles with Primary Amines Affording Quinazolinones

A selective functionalization of C-C-C bonds toward N-C-O bonds is realized by an n-Bu4NI-catalyzed reaction of 3-methylindoles with primary amines using TBHP as the unique oxidant. The systematic process involves oxygenation, nitrogenation, ring-opening, and recyclization, affording a broad range of quinazolinones in good to excellent yields.

Transition metal-free synthesis of quinazolinones using dimethyl sulfoxide as a synthon

Biologically important quinazolinones have been synthesized from 2-aminobenzamides and DMSO. The key feature of the reaction is the utilization of DMSO as a methine source for intramolecular oxidative annulation. The CNS depressant drug methaqualone has also been synthesized by our methodology. The present method involves the synthesis of quinazolinones with a broad substrate scope and a good yield.