146667-84-7 Usage
General Description
3-(2-Hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester, also known as Tert-butyl 3-(2-hydroxyethyl)piperidine-1-carboxylate, is a chemical compound used in the synthesis of pharmaceuticals and agrochemicals. It is a tert-butyl ester derivative of a piperidine carboxylic acid with an added hydroxyl ethyl group. 3-(2-Hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester is commonly utilized in the development of new drugs and active pharmaceutical ingredients due to its unique structural properties and potential biological activity. Additionally, it may also have applications in the production of pesticides and other agricultural products.
Check Digit Verification of cas no
The CAS Registry Mumber 146667-84-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,6,6 and 7 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 146667-84:
(8*1)+(7*4)+(6*6)+(5*6)+(4*6)+(3*7)+(2*8)+(1*4)=167
167 % 10 = 7
So 146667-84-7 is a valid CAS Registry Number.
InChI:InChI=1/C12H23NO3/c1-12(2,3)16-11(15)13-7-4-5-10(9-13)6-8-14/h10,14H,4-9H2,1-3H3
146667-84-7Relevant articles and documents
CCR3 antagonists: a potential new therapy for the treatment of asthma. Discovery and structure-activity relationships.
Wacker, Dean A,Santella 3rd., Joseph B,Gardner, Daniel S,Varnes, Jeffrey G,Estrella, Melissa,DeLucca, George V,Ko, Soo S,Tanabe, Keiichi,Watson, Paul S,Welch, Patricia K,Covington, Maryanne,Stowell, Nicole C,Wadman, Eric A,Davies, Paul,Solomon, Kimberly A,Newton, Robert C,Trainor, George L,Friedman, Steven M,Decicco, Carl P,Duncia, John V
, p. 1785 - 1789 (2007/10/03)
CCR3 antagonist leads with IC(50) values in the microM range were converted into low nM binding compounds that displayed in vitro inhibition of human eosinophil chemotaxis induced by human eotaxin. In particular, 4-benzylpiperidin-1-yl-n-propylureas and erythro-3-(4-benzyl-2-(alpha-hydroxyalkyl)piperidin-1-yl)-n-propylureas (obtained via Beak reaction of N-BOC-4-benzylpiperidine) exhibited single digit nanomolar IC(50) values for CCR3.
Synthesis of 3-Vinylpiperidine
Lowen, Gregory T.,Almond, Merrick R.,Rideout, Janet L.
, p. 1663 - 1665 (2007/10/02)
A novel synthesis of 3-vinylpiperidine from commercially available ethyl 3-pyridylacetate is described.
