147083-36-1

Basic information

• Product Name: 11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]iMidazo[1,2-a]azepine
• Synonyms: 11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]iMidazo[1,2-a]azepine;CL136
• CAS NO: 147083-36-1
• Molecular Formula: C18H21N3
• Molecular Weight: 279.37944
• EINECS: -0
• Mol File: 147083-36-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 501.1±60.0 °C(Predicted)
• Appearance: /
• Density: 1.19±0.1 g/cm3(Predicted)
• PKA: 8.71±0.20(Predicted)
• CAS DataBase Reference: 11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]iMidazo[1,2-a]azepine(CAS DataBase Reference)
• NIST Chemistry Reference: 11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]iMidazo[1,2-a]azepine(147083-36-1)
• EPA Substance Registry System: 11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]iMidazo[1,2-a]azepine(147083-36-1)

Safety Data

• Hazardous Substances Data: 147083-36-1(Hazardous Substances Data)

Usage

General Description

"11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepine" is a complex organic compound, that belongs to the category of azepines, which are organic compounds containing a seven-membered heterocycle made from five carbon atoms and two nitrogen atoms at ring positions 1 and 4. The detail structure of this compound includes a 1-methylpiperidin-4-ylidene group attached to a benzo[d]imidazo[1,2-a]azepine, which is a dihydro derivative of 5H-benzo[d]imidazo[1,2-a]azepine. The exact properties, uses, and hazards of this specific compound are not readily available, possibly because it's a lesser-known or less-researched substance. As with any chemical compound, safe handling and appropriate personal protective equipment should be used to prevent exposure.

Upstream product

• 24252-37-7 ethyl 1-methylisonipecotate 
• 60-12-8 2-phenylethanol 
• 118133-15-6 1-ethoxycarbonylpiperidine-4-carboxylic acid 
• 498-94-2 isonipecotic acid 
• 50-00-0 formaldehyd 
• 142654-73-7 11-piperidin-4-ylidene-6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine 
• 49823-14-5 1-(2-phenylethyl)-1H-imidazole 

Relevant articles and documents

METHODS FOR THE PREPARATION OF ALCAFTADINE

The invention relates to new and improved processes for the preparation of Alcaftadine and pharmaceutically acceptable salts thereof as well as an intermediate for the preparation of Alcaftadine. The new process saves a number of steps compared to the known process and results in a higher yield.

Imidazo[2,1-b]benzazepine derivatives, compositions and method of use

The present invention is concerned with novel imidazo[2, 1-b][3]benzazepines of formula STR1 the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein each of the dotted lines independently represents an optional bond; R1 represents hydrogen, halo, C1-4 alkyl or C1-4 alkyloxy; R2 represents hydrogen, halo, C1-4 alkyl or C1-4 alkyloxy; R3 represents hydrogen, C1-4 alkyl, ethenyl substituted with hydroxycarbonyl or C1-4 alkyloxycarbonyl, C1-4 alkyl substituted with hydroxycarbonyl or C1-4 alkyloxycarbonyl, hydroxyC1-4 alkyl, formyl or hydroxycarbonyl; R4 represents hydrogen, C1-4 alkyl, hydroxyC1-4 alkyl, phenyl or halo; R5 represents hydrogen, C1-4 alkyl or halo; L represents hydrogen; C1-6 alkyl; C1-6 alkyl substituted with one substituent selected from the group consisting of hydroxy, halo, C1-4 alkyloxy, hydroxycarbonyl, C1-4 alkyloxycarbonyl, C1-4 alkyloxycarbonyl-C1-4 alkyloxy, hydroxycarbonylC1-4 alkyloxy, C1-4 alkyloxycarbonylamino, C1-4 alkylaminocarbonyl, C1-4 alkylaminocarbonylamino, C1-4 alkylaminothiocarbonylamino, aryl, aryloxy and arylcarbonyl; C1-6 alkyl substituted with both hydroxy and aryloxy; C3-6 alkenyl; C3-6 alkenyl substituted with aryl; or, L represents a radical of formula --Alk--Y--Het1 (a-1),--Alk--NH--CO--Het2 (a-2)or --Alk--Het3 (a-3); provided that 6,11-dihydro-11-(4-piperidinylidene)-5H-imidazo[2,1-b][3]benzazepine is ecxluded, which are useful antiallergic compounds. Compositions comprising said compounds, methods of using and processes for preparing the same.